This book constitutes the refereed proceedings of the First International Conference on Smart and Sustainable Agriculture, SSA 2021, held as a virtual event in June 2021. The 12 papers presented were thoroughly reviewed and selected from the 25 qualified submissions. The papers provide discussion on new trends in communication and networking, Internet of Things, data processing for smart agriculture, renewable-energy based devices, low-cost solutions for wide-area exploitations and developing countries, smart agriculture and urban farming, smart irrigation, application to small-size andlarge-size exploitations, application of ancestral farming to smart agriculture, waste management for agriculture 2.0, and census of regional ancestral farming.