Sleep, Circadian Rhythms, and Metabolism

William Olds has an undergraduate degree from University of Michigan and is working on his graduate degree at Yale University, New Haven, Connecticut, USA, in the laboratory of Tian Xu. His current research focuses on satiety signals from the gut and how that communication to the brain breaks down in the pathogenesis of obesity.

• Introduction. Introduction: The Watch Inside all of Us. Regulation of Prokineticin 2 Expression by Light and the Circadian Clock. Circadian Signatures in Rat Liver: From Gene Expression to Pathways. Body Weight, Metabolism, and Clock Genes. Metabolism at Night versus the Morning. Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork. Circadian Rhythms and Obesity in Mammals. Food and the Circadian Activity of the Hypothalamic-Pituitary-Adrenal Axis. Circadian and Dark-Pulse Activation of Orexin/Hypocretin Neurons. Meal Time Shift Disturbs Circadian Rhythmicity Along with Metabolic and Behavioral Alterations in Mice. A Metabolic–Transcriptional Network Links Sleep and Cellular Energetics in the Brain. Effects of Artificial Light and Sleep Disruption on Metabolism. Pathophysiology and Pathogenesis of Circadian Rhythm Sleep Disorders. Shift Work. A New Approach to Understanding the Impact of Circadian Disruption on Human Health. Waking and Sleeping in the Rat Made Obese Through a High-Fat Hypercaloric Diet. Effect of Sleep Deprivation on Brain Metabolism of Depressed Patients. Index.

"This is a compilation of recent research in the field of circadian rhythms, sleep, and metabolism, exploring the connections between these concepts and how perturbations of these rhythms manifest in disorders of metabolism and sleep. ... The primary audience is researchers and scientists with an interest in the interrelationship between circadian neurobiology, metabolism, and sleep. ... This is a noteworthy contribution to the field that brings together current knowledge at the intersection of circadian rhythms, sleep, and metabolism."—M. Isabel L. Crisostomo, MD, Rush University Medical Center, writing Doody's Book Reviews