Del 33 - Translational Epigenetics

Site Specific and Global Epigenomic Editing

Nyhet

Principles and Applications

Häftad, Engelska, 2026

Av Feng C Zhou, USA) Zhou, Feng C (Professor of Anatomy, Cell Biology, Neuroscience, and Psychology, Emeritus; Adjunct Professor of Behavioral Psychology, Northwestern University, Indianapolis, IN, Feng C. Zhou, Trygve Tollefsbol

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Site Specific and Global Epigenomic Editing: Principles and Applications, Volume 33 highlights the expanding role that epigenetics plays in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. The book answers key questions, including which of the hundreds of epigenomic marks and features are relevant, and which are likely to serve a role in regulating gene expression, cell behavior and phenotypic outcomes. This volume is the first to provide a thorough, conceptual introduction to epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation.

Included protocols and applied case studies examine early disease targets and likely pathways of therapeutic significance while also outlining common challenges in the field. The book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research.

Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery
Discusses fundamental theory, experimental design and applied approaches alongside common research challenges and bioethical concerns
Examines epigenomic editing’s potential role in the modulation of developmental, neuropsychiatric and immunological disorders, as well as in viral infections and cancer

Produktinformation

Utgivningsdatum2026-06-01
Mått191 x 235 x undefined mm
FormatHäftad
SpråkEngelska
SerieTranslational Epigenetics
Antal sidor704
FörlagElsevier Science
ISBN9780128193983

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Dr. Feng C. Zhou is Professor Emertus of Anatomy and Cell Biology at Indiana University School of Medicine, Indianapolis, Indiana. In his research, Dr. Zhou studies genetic contributions to gene expression that underpin the neurochemical and neuroanatomical differences contributing to alcohol addiction. His previous research has demonstrated that alcohol alters expression cohorts of neural specification genes, and cell cycling genes in the canonical developmental pathways. In recent years, Dr. Zhou has expanded his research to include the genomics and epigenetics of alcoholism, epigenetic editing by optogenetics, cell-wide DNA de-methylation and re-methylation of purkinje neurons in the developing cerebellum, and environmental alterations of epigenetics prior to the birth, among other topics. Dr. Zhou has published widely in scientific, peer reviewed journals including Scientific Reports, PLoS ONE, Oncotarget, Frontiers in Genetics, Brain Research, Cell Transplantation, and Alcohol. Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Part I EPIGENETICS AND EPIGENOMICS1. Epigenetic editing: Progress and Challenges 2. Epigenetic dynamics: Normal progression and abnormal alteration 3. Epigenomic landscape 4. Histone coding and its compounding influence on gene expression5. microRNA as a tool for gene regulation6. RNA editing and genetic influence 7. Epitranscription: Scope and engineering abilityPart II GLOBAL EPIGENETIC EDITING8. Global epigenetic editing uses methods of DNA methylation alteration drugs 9. Regulating DNA methylation for developmental disorders 10. Histone modification drug the HDACi: Selectivity and promise 11. Histone modification in cancer treatment12. Alteration of DNA Methylation in gastric cancer13. Epigenetic therapy for the treatment of epithelial ovarian cancer14. Epigenetic application on allergy treatment15. HDACi therapy for the treatment of depression 16. Histone modification on neurodevelopmental and neuropsychiatric disorders 17. Epigenetics and Addiction 18. Epigenetic Treatment of Persistent Viral Infections19. MicroRNA as strategy of gene regulationPart III SITE SPECIFIC EPIGENETIC EDITING20. Strategy and Molecular tools for site-specific editing 21. Site-specific recruitment of epigenetic factors for spatio-temporal epigenetic editing. 22. Monitoring CRISPR-Cas9 mediated DNA-methylation-editing 23. Locus-specific editing of histone modifications24. Functional DNA methylation and epigenetic editing on proneuron genes during neuroglial differentiation25. Epigenetic editing through regulating CRISPR-Cas9 mediated non-coding RNA26. Epigenetic editing targeting a parkinsonian gene 27. Cancer gene epigenetic editing 28. Epigenetic editing to unveil epigenetic mechanism of breast cancer29. Editing DNA Methylation on Fragile X syndrome 30. Can RNA editing be engineered?31. Genetic and epigenetic interactive approachesPart IV TRANSLATIONAL AND CLINIC APPLICATION32. Tuning DNA methylation in treating breast cancer: 33. Imminent Epigenetic editing in cancer treatment34. Epigenetic editing for developmental disorders35. Epigenetic editing on genetic imprinting36. Prospective epigenetic treatment on Neurological disease37. Epigenetic alterations and personalized treatment in cancerPart V CLOSING VIEW38. Obstacles and prospective of changing epigenetic codes39. Ethical matters in modification of epigenetic codes40. Future epigenetic treatment