Sirtuin Biology in Medicine

Kenneth Maiese, MD, is an internationally recognized physician-scientist whose investigations are designed to translate basic science into successful therapeutic treatments. He maintains therapeutic and scientific expertise in multiple medical disciplines and has been fortunate to receive recognition with outstanding teaching and investigator awards, election to America’s Top Physicians and The Best of U.S. Physicians, recipient of Albert Nelson Marquis Lifetime Achievement Award, and elected as an America’s Health Insurance Plans (AHIP) Executive Leadership Fellow. His work has received the distinction of “High Impact Research and Potential Public Health Benefit” by the National Institutes of Health. As an internationally recognized physician researcher and “C-suite” healthcare leader, he has extensive experience in academic medicine, healthcare delivery, business development, managed care, biotechnology, and drug development holding positions as member and advisor for the National Institutes of Health Biotechnology and Venture Capital Development, National Institutes of Health Innovation Network, Chief Medical Officer, tenured Professor and Chair and Chief of Service of the Department of Neurology and Neurosciences of Rutgers University, Global Head of Translational Medicine and External Innovation, Board Member of the Cancer Institute of New Jersey, Steering Committee Member for the Foundation for the National Institutes of Health, tenured Professor in Neurology, Anatomy & Cell Biology, Molecular Medicine, the Barbara Ann Karmanos Cancer Institute, and the National Institute of Health Center at Wayne State University, and Founding Editor and Editor-in-Chief of multiple highly successful international journals.

• Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging 1. Novel treatment strategies for neurodegenerative disease with sirtuinsKenneth Maiese 2. NAD1: a crucial regulator of sirtuin activity in agingNady Braidy And Maria Villalva (D.) 3. Sirtuins and life span extensionShin-Hae Lee and Kyung-Jin Min 4. Sirtuins and agingBrian J. Morris 5. Sirtuins in the biology of agingMateusz Wątroba And Dariusz Szukiewicz 6. Sirtuins as regulators and the regulated molecules of exosomesQing Han, Yirui Cheng, and Weiliang Xia 7. Sirtuins in aging, age-related pathologies and their association with circadian rhythmSankarathi Balaiya 8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s diseaseG. Anderson and M. Maes 9. Sirtuins, melatonin, and the relevancevof circadian oscillatorsRüdiger Hardeland10. Epigenetic role of sirtuins in neurodegenerative brain disordersArchita Khanna, Anamika, and Surendra Kumar Trigun 11. Sirtuins and stem cell maintenance, proliferation, and differentiationRyan A. Denu and Peiman Hematti 12. Sirtuins in mechanistic target of rapamycin complex 1 signalingJ. Burillo, P. Marqués, B. Jiménez, C. González-Blanco, M. Benito, and C. Guillén 13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliabilityVitaly K. Koltover and Tatjana A. Skipa 14. Sirtuins, mitochondria, and exercise in health and diseaseAnibh M. Das and Partha DabkeSection II: Sirtuins, cardiovascular disease and end-organ disease 15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complicationsBugga Paramesha and Sanjay K. Banerjee 16. Role of sirtuins in cardiovascular diseasesVenkatraman Ravi, Sneha Mishra, and Nagalingam Ravi Sundaresan17. Targeting sirtuins to modulate energy metabolism in heart diseaseTsunehisa Yamamoto and Ken Shinmura 18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injuryHassan Farghali, Mighty Kgalalelo Kemelo, and Nikolina Kutinová Canová 19. Sirtuins as key players in aging and kidney dysfunctionLuca Perico and Ariela Benigni 20. Role of sirtuins in liver diseasesD. Ezhilarasan and M. Najimi 22. Vitagenes in avian biology: protective functions of sirtuinsPeter F. Surai, Ivan I. Kochish, and Vladimir I. Fisinin 23. Sirtuins in hematopoiesis and blood malignanciesBerta N. Vazquez, Irene Fernández-Duran, and Alejandro Vaquero Index

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