Silk-Based Biomaterials for Tissue Engineering, Regenerative and Precision Medicine

Subhas C. Kundu, PhD, is a Research Coordinator and former European Research Area Chair and Professor at the 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of the University of Minho, Portugal. His research interests include silk biomaterial matrices for biomedical applications, including 3D in vitro cancer models for investigating tumour growth and progression. In addition, he is using natural-based biomaterials for 3D cancer modelling and drug screening. Rui L. Reis, PhD, DSc, Hon. Causa MD, Hon Causa PhD, FBSE, FTERM, Dean of I3Bs - Institute on Biomaterials, Biodegradables and Biomimetics, Founding Director of the 3B’s Research Group, and Director of the PT Government ICVS/3B´s Associate Laboratory. He is the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine. He was the Global President of the Tissue Engineering and Regenerative Medicine International Society (TEMIS) and the former editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He received several major international awards and is the Associated Editor of PNAS Nexus. He is the chair of the Fellows of all the international societies on biomaterials sciences and engineering (FBSE). His research interest is tissue engineering, regenerative medicine, biomaterials and, increasingly, the development of 3D tissue-engineered disease models for the next generation of high-throughput predictive clinical tools, namely using living optical fibres based on the combination of living cells and hydrogels for the better understanding and optimizing of biomaterial/cell interactions.

• 1. Historical Silk Biomaterials2. Processing of Bombyx mori silk for use in biomedical and regenerative applications3. Cellular interaction with sericin: A basis for non-communicable and infectious diseases4. Tunable silk-based matrices using ionic liquids and their biomedical applications5. Biodegradability of silk biomaterials6. Engineering enzymatic and photo-crosslinked silk-based hydrogels for regenerative medicine7. Vascularization in porous silk fibroin as therapeutic biomaterials8. Structure and properties of spider and silkworm silk for tissue engineering, scaffolds and medicine9. Recent trends in controlled drug delivery based on silk platforms10. Silk for cardiac tissue engineering11. Silk proteins for bioelectronic devices in healthcare 12. Silk optics and electronics13. Silk biomaterials for tendon and tendon-to-bone enthesis tissue engineering14. Spider silks and their blends as biomaterials: Recent advances and future opportunities15. Silk fibroin nanofibers and blends for skin tissue engineering applications16. 3D Bioprinting of Articular Cartilage using Silk Fibroin-Gelatin Bioink17. Artificial silk fibers as biomaterials and their applications in biomedicine18. Translation of a silk-based medical device from bench to bedside19. Immune responses to silk proteins in vitro and in vivo: Lessons learnt20. Assembling silk into nanomedicines21. Silk scaffolds for dental tissue engineering (subject to change)22. 3D bioprinting using silk biomaterial ink: Where we are trying to move?23. Non-mulberry silk based biomaterials: Biomedical applications, current status and future perspective24. Silk protein: An emerging biomaterial for tumor modeling25. Microfibrillated silks and their potential applications26. Trends in silk biomaterials: technological advances and future strategies27. Silk fibroin smart hydrogels: Recent progress in tissue engineering and regenerative medicine28. Microfluidic Engineering of Silk Fibroin Biomaterial