Signalling Pathways in Acute Oxygen Sensing

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• Symposium on Signalling pathways in acute oxygen sensing, held at the Novartis Foundation, London, 25–27 January 2005. Editors: Derek J. Chadwick (Organizer) and Jamie Goode.This symposium is based on a proposal made by Jeremy Ward.Michael Duchen Chair’s introduction.Gregg L. Semenza, Larissa A. Shimoda and Nanduri R. Prabhakar Regulation of gene expression by Hypoxia-Inducible Factor.Discussion.Ineke P. Stolze, David R. Mole and Peter J. Ratcliffe Regulation of HIF: prolyl hydroxylases.Discussion.General discussion I.Daniel Peet and Sarah Linke Regulation of HIF: asparaginyl hydroxylation.Discussion.José López-Barneo, Patricia Ortega-Sáenz, José I. Piruat and María García-Fernández Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells.Discussion.Keith J. Buckler, Beatrice A. Williams, Rodrigo Varas Orozco and Christopher N. Wyatt The role of TASK-like potassium channels in oxygen sensing in the carotid body.Discussion.Nanduri R. Prabhakar, Ying-Jie Peng, Guoxiang Yuan and Ganesh K. Kumar Reactive oxygen species facilitate oxygen sensing.Discussion.C. A. Nurse, J. Buttigieg, R. Thompson, M. Zhang and E. Cutz Oxygen sensing in neuroepithelial and adrenal chromaffin cells.Discussion.C. Peers, P. Kang, J. P. Boyle, K. E. Porter, H. A. Pearson, I. F. Smith and P. J. Kemp Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells.Discussion.General discussion II.Paul J. Kemp, Sandile E. J. Williams, Helen S. Mason, Phillippa Wootton, David E. Iles, Daniela Riccardi and Chris Peers Functional proteomics of BK potassium channels: defining the acute oxygen sensor.Discussion.Stephen L. Archer, Evangelos D. Michelakis, Bernard Thébaud, Sebastien Bonnet, Rohit Moudgil, Xi-Chen Wu and E. Kenneth Weir A central role for O2-sensitive K+ channels and mitochondria in the specialized O2-sensing system.Discussion.Gregory B. Waypa and Paul T. Schumacker Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction.Discussion.Norbert Weissmann, Ralph T. Schermuly, Hossein A. Ghofrani, Jörg Hänze, Parag Goyal, Friedrich Grimminger and Werner Seeger Hypoxic pulmonary vasoconstriction—triggered by an increase in reactive oxygen species?.Discussion.General discussion III.Alison M. Gurney and Shreena Joshi The role of twin pore domain and other K+ channels in hypoxic pulmonary vasoconstriction.Discussion.A. Mark Evans, D. Grahame Hardie, Antony Galione, Chris Peers, Prem Kumar and Christopher N. Wyatt AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific calcium signalling mechanisms in oxygen-sensing cells.Discussion.Silke Becker, Gregory A. Knock, Vladimir Snetkov, Jeremy P. T. Ward and Philip I. Aaronson Role of capacitative Ca2+ entry but not Na+/Ca2+ exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries.Discussion.Final general discussion.Index of contributors.Subject index.

"This an excellent resource for those in the field of oxygen sensing." (Doody's Health Services)