Signaling Pathways in Breast Cancer

Signaling Pathways in Breast Cancer: Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance provides an in-depth exploration of the complex molecular mechanisms that drive breast cancer progression. The book focuses on critical signaling pathways, including PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, Wnt/?-catenin, and Notch, elucidating their roles in tumor development, survival, and therapeutic resistance. The content offers a comprehensive overview of these pathways, detailing their dysregulation in breast cancer and the implications for targeted therapeutic strategies. It discusses FDA-approved treatments, emerging therapies, and the mechanisms behind drug resistance, integrating recent research findings to highlight novel molecular targets and biomarker discovery. This book serves as a valuable resource for researchers, clinicians, and students, bridging the gap between basic molecular biology and clinical applications. By providing structured insights into complex signaling networks and therapeutic interventions, it equips the audience with essential knowledge for developing innovative approaches to breast cancer management and improving patient outcomes.

• Provides a detailed exploration of critical signaling pathways such as PI3K/Akt, MAPK, JAK/STAT, and Notch, elucidating their roles in tumor initiation, progression, and resistance to therapy
• Discusses FDA-approved targeted therapies and emerging treatment strategies, including immunotherapy and personalized medicine, while addressing mechanisms of drug resistance and potential strategies to overcome it
• Includes case studies and biomarker-based approaches that link molecular mechanisms to clinical outcomes, offering insights into ongoing clinical trials and future directions in breast cancer therapy