Signaling Pathways for Translation

Insulin and Nutrients

Inbunden, Engelska, 2001

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This book deals with anabolic mechanisms which regulate eukaryotic protein synthesis, with particular emphasis on insulin and amino acids. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. The regulation of both the eIF2 and eIF4 groups of initiation factors by signal transduction mechanisms is presented, and translation is related to cellular growth in response to nutrient and hormonal signals.

Produktinformation

Utgivningsdatum2001-07-17
Mått155 x 235 x 16 mm
Vikt471 g
FormatInbunden
SpråkEngelska
SerieProgress in Molecular and Subcellular Biology
Antal sidor186
Upplaga2001
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783540417095

Tillhör följande kategorier

Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Insulin Signaling and the Control of PHAS-I Phosphorylation.- 1 Introduction.- 2 Mechanism of Translational Repression.- 3 PHAS Isoforms.- 4 Phosphorylation Sites in PHAS-I.- 5 Protein Kinases That Phosphorylate PHAS-I in Vitro.- 6 Control by Hormones, Nutrients, and cAMP.- References.- Insulin, Phorbol Ester and Serum Regulate the Elongation Phase of Protein Synthesis.- 1 Introduction.- 2 Structure and Function of EF-1 and EF-2.- 3 Modifications of EF-1 and EF-2.- 4 Regulation of Elongation by Insulin Via Multipotential S6 Kinase and EF-2 Kinase.- 5 Regulation of Elongation by Phorbol Ester Via Protein Kinase C.- 6 Regulation of Elongation during the Cell Cycle by Cdc2.- 7 Lack of Regulation of Elongation by Protein Kinase Casein Kinase II.- 8 Conclusions.- References.- Regulation of Protein Synthesis by Insulin Through IRS-1.- 1 Introduction.- 2 Materials and Methods.- 3 Results.- 4 Discussion.- References.- Regulation of Eukaryotic Initiation Factor eIF2B.- 1 Function and Structure of eIF2B.- 2 eIF2B Activity Can Be Regulated by the Phosphorylation of eIF2?.- 3 Regulation of eIF2B Activity in Vivo.- 4 Mechanisms Involved in the “Direct” Regulation of eIF2B Activity.- 5 Other Phosphorylation Sites in eIF2B.- 6 Other Inputs into the Control of eIF2B.- 7 Conclusions and Perspectives.- References.- The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity.- 1 Identification of the p70 S6 Kinase.- 2 Expression and Structure.- 3 Substrate Specificity and Selection.- 4 Cellular Function(s).- 5 Regulation of the p70 S6 Kinase.- 6 TOR Regulates Cell Function in Response to the Nutrient Milieu.- 7 p70 is Regulated by Multisite (Ser/Thr) Phosphorylation.- 8 RTK Recruitment of Type 1A PI-3 Kinases Activates p70 S6 Kinase.- 9 The Mechanism ofp70 Activation by PI-3 Kinase and the Role of PDK1.- 10 Candidate “p70 Thr412 Kinases”.- 11 Conclusion.- References.- Regulation of Translation Initiation by Amino Acids in Eukaryotic Cells.- 1 Introduction.- 2 Regulation by Amino Acids of met-tRNAi Binding to 40 S Ribosomal Subunits.- 3 Regulation of mRNA Binding to 40 S Ribosomal Subunits by Amino Acids.- 4 Is There Coordinated Regulation by Amino Acids of Translation Initiation and Elongation?.- 5 Summary.- References.