Del i serien Progress in Experimental Cardiology

Signal Transduction and Cardiac Hypertrophy

Inbunden, Engelska, 2003

AvNaranjan S. Dhalla,Larry Hryshko,Naranjan S. Dhalla,Larry Hryshko,Elissavet Kardami,Pawan K. Singal

2 949 kr

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The limitation in number of donor hearts led to the establishment of alternative treatments such as left ventricular assist devices (LVAD), which have been used. Although several reports suggest the native ventricular function recovers after long-term LVAD support - a process called "reverse remodelling" - the underlying biological mechanisms are unclarified. Various molecular pathways of the human myocardium associated with apoptosis, response to stress, or matrix changes are known to be altered under conditions of heart failure and some of them have been shown to be reversible regulated during left ventricular mechanical support. This suggests that the "reverse remodelling" is actually, at least in part, a reverse mechanism. One explanation may be, under mechanical circulatory assist, volume and pressure overload is reduced, and thus ventricular wall stress decreases, leading to improved myocardial blood supply. This may be one explanation for the molecular myocardial changes, and may reflect a possible cause of "reverse remodelling".

Produktinformation

Utgivningsdatum2003-01-31
Mått155 x 235 x 30 mm
Vikt857 g
FormatInbunden
SpråkEngelska
SerieProgress in Experimental Cardiology
Antal sidor508
Upplaga2003
FörlagKluwer Academic Publishers
ISBN9781402072185

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I. Cardiac Adaptation and Remodeling.- 1. Molecular Changes of the Myocardium after Mechanical Circulatory Support.- 2. Reverse Molecular Remodeling of the Failing Human Heart Following Support with a Left Ventricular Assist Device.- 3. Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart.- 4. L-Arginine at the Crossroads of Biochemical Pathways Involved in Myocardial Hypertrophy.- 5. Signal Transduction System in Human Aortic Smooth Muscle Cell Stimulated by Pure Pressure.- 6. Role of Mitochondrial KATP Channels in Improved Ischemic Tolerance of Chronically Hypoxic Adult and Immature Hearts.- 7. Ca2+–Dependent Signaling Pathways Through Calcineurin and Ca2+/Calmodulin–Dependent Protein Kinase in Development of Cardiac Hypertrophy.- 8. Calreticulin, Cardiac Development and Congenital Complete Heart Block in Children.- 9. Expression of Sodium-Calcium Exchanger Genes in Heart and Skeletal Muscle Development. Evidence for a Role of Adjacent Cells in Regulation of Transcription and Splicing.- 10. Na+/H+ Exchanger and Myocardial Hypertrophy.- II. Cardiac Signal Transduction.- 11. Role of the Electrogenic Na+/HCO3- Symport in the Heart.- 12. Modulation of Atrial Natriuretic Peptide (ANP)-C Receptor and Associated Signaling by Vasoactive Peptides.- 13. RAB3 Small GTP–Binding Proteins: Regulation by Calcium/Calmodulin.- 14. Novel Aspects of Mechanical Signaling in Cardiac Tissue.- 15. Caspase Activation in a Cardiac Cell-Free Model of Apoptosis.- 16. The Role of the Voltage-Sensitive Release Mechanism in Contraction of Normal and Diseased Heart.- 17. Role of AT1 Receptor Blockade in Reperfused Myocardial Infarction.- 18. Relation Between Intracellular Ca2+ Concentration and Contraction in Tetanized Myocyctes of Rat and Mouse.- 19. The Role of Hydrogen Peroxide as aSignaling Molecule.- 20. Localized Control of Oxidative Phosphorylation within Intracellular Energetic Units in Heart Cells: A Possible Solution of Some Old Problems.- 21. Role of High Molecular Weight Calmodulin Binding Protein in Cardiac Muscle.- 22. ?-Adrenergic Signaling in Chronic Heart Failure—Friend or Foe?.- 23. Compartmentation to Lipid Rafts as a Mechanism to Regulate ?-Adrenergic Receptor Signaling in Cardiomyocytes.- 24. Role of Renin-Angiotensin System in Phospholipase C-Mediated Signaling in Congestive Heart Failure.- 25. JAK/Stat Signaling in Cardiac Diseases.- III. Genetic Approaches to Investigative Cardiac Signal Transduction.- 26. Signaling Pathways Involved in the Stimulation of DNA Synthesis by Tumor Necrosis Factor and Lipopolysaccharide in Chick Embryo Cardiomyocytes.- 27. The Application of Genetic Mouse Models to Elucidate a Role for Fibroblast Growth Factor-2 in the Mammalian Cardiovascular System.- 28. Interaction of COUP-TF II With the Rat Carnitine Palmitoyltransferase I B Promoter in Neonatal Rat Cardiac Myocytes.- 29. Altered Expression of Conventional Calpains Influences Apoptosis.- 30. KLF5/BTEB2, a Krüppel-Like Transcription Factor, Regulates Smooth Muscle Phenotypic Modulation.- 31. Transgenic Manipulation of SERCA and PLB Levels and Their Effect on Cardiac Contractility.- 32. Expression of Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor 1? in the Myocardium.- 33. Gene-Based Therapy of Advanced Heart Failure Secondary to the Disruption of Dystrophin-Related Proteom.- 34. Adaptation to Ischemia by In Vivo Exposure to Hyperoxia-Signalling Through Mitogen Activated Protein Kinases and Nuclear Factor Kappa B.- 35. The SERCA2 Gene: Genomic Organization and Promoter Characterization.

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