VIPUL N. MANKAD, a physician scientist and a pediatric hematologist-oncologist, is Louise Lenoir Lock Distinguished Professor and Vice Chairman of Pediatrics. He is a Senior Scientist at the Comprehensive Sickle Cell Center at the University of South Alabama College of Medicine.R. BLAINE MOORE, a biochemist and red cell scientist is an Associate Director and a Scientist at the Comprehensive Sickle Cell Center at the University of South Alabama College of Medicine. He is also an Associate Professor of Pediatrics and Biochemistry at South Alabama.

• Preface Introduction: Epidemiology and Population Genetics of Sickle Cell Disease and the Sickle Cell Trait by Vipul N. Mankad and Charles Hoff Basic Science Aspects of Sickle Cell Disease Molecular Aspects of Polymerization of Hemoglobin by A. Seetharama Acharya Pathophysiology of the Sickle Cell by R. Blaine Moore Interactions of Blood Cells and Vascular Endothelium in Sickle Cell Disease: Eicosanoids as Signals and Modulators by Gesina L. Longenecker Anatomical Lesions in Sickle Cell Hemoglobinopathies by Lemuel W. Diggs Clinical Diagnosis and Management of Sickle Cell Disease Diagnosis of Sickle Cell Disease and Its Related Hemoglobinopathies Disorders by Yih-Ming Yang, Susan Brigham, and Paul I. Liu Screening for Sickle Cell Disease by Yih-Ming Yang and Paul I. Liu Hematological Manifestations of Sickle Cell Disease by Vipul N. Mankad Conventional and Experimental Approaches to Management of Acute Vaso-Occlusive Pain (Painful Crises) by Lennette J. Benjamin Infection in Sickle Cell Disease by Marilyn H. Gaston and Clarice D. Reid Neurological Complications of Sickle Cell Disease by Vipul N. Mankad and Paul R. Dyken Hepatobiliary, Renal, and Pulmonary Complications in Sickle Cell Disease by Vipul N. Mankad and Yih-Ming Yang Radiological Implications of Sickle Cell Disease by B. Gil Brogdon, Myron L. Lecklitner, Byron C. Machen, and John Powell Williams Anesthetic Management of Patients with Sickle Cell Disease by Aparna V. Mankad Surgical Management of Patients with Sickle Cell Syndromes by John P. Sutton, John J. Farrer, and Charles B. Rodning Psychosocial Aspects of Sickle Cell Disease Diagnosis and Management of Psychosocial Problems in the Sickle Cell Disease Patient and Family by Kermit B. Nash Bibliography Index