Anca Trifan, MD, PhD, FEBGH, FRCP (London), Professor of Gastroenterology and Internal Medicine, and Director of the Department of Internal Medicine of the “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, is also Head of the Institute of Gastroenterology and Hepatology, Iasi, Romania. Her research interests include inflammatory bowel disease, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, biliary tract disorders, and Clostridioides difficile infection. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact factor journals. She has been involved in medical teaching since the beginning of her career. She received many prizes from scientific organizations (e.g., Rising Stars in Gastroenterology awarded by UEG). She is a past president of the Romanian Society of Gastroenterology and Hepatology, a member of the Academy of Medical Sciences, a member of the European Board of Gastroenterology, an AGA fellow, and a member of the American Association for the Study of Liver Diseases.Carol Stanciu, MD, PhD, FRCP (London), Professor of Gastroenterology and Internal Medicine at the University of Medicine and Pharmacy “Gr. T. Popa,” Iasi, Fellow of the Academy of Medical Sciences, and Fellow of the Romanian Academy, Dr. Carol Stanciu (born May 17, 1937; Hasdat, Hunedoara, Romania) is one of the main founders of gastroenterology, diagnostic and therapeutic endoscopy in Romania. He graduated from the Faculty of Medicine, University of Medicine and Pharmacy “Gr.T.Popa” Iasi (1963) where he also received his PhD and DSc, and served as Assistant, Associate Professor, and Professor of the Department of Internal Medicine and Gastroenterology. He is the former Rector of the University of Medicine and Pharmacy “Gr.T.Popa” Iasi (1992-2004), Dean of the Faculty of Medicine (2004-2008), President of the Romanian Society of Endoscopy (1996-2000), President of the Romanian Society of Gastroenterology and Hepatology (2000-2008), and Chairman of the Ethics Committee of the World Organization of Gastroenterology (1994-2002). He has always been involved in all areas of academic life: medical training, especially therapeutic endoscopy, patient care, administrative work, and mentorship. His research interests include gastrointestinal motility, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, inflammatory bowel disease, biliary tract disorders, and Clostridium difficile infection. He has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of prestigious high-impact factor journals. He received many awards from the Romanian Presidency, French Presidency, WGO, Romanian Society of Gastroenterology and Hepatology, and many universities.Liana Gheorghe, MD, PhD, Professor of Gastroenterology and Hepatology, Department of Clinical Education of the Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, and Head of the 3rd Clinic of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. She is the President of the Romanian Association for Liver Disease, a highly active, non-profit medical association founded in 2018 aiming to disseminate science and the practice of hepatology in Romania. Also, she is the current president of the Romanian Society of Gastroenterology and Hepatology, an active member of the European Crohn's and Colitis Organization, the Romanian Crohn's and Colitis Club, and the European Society for Parenteral and Enteral Nutrition. Her research interests include inflammatory bowel disease, liver transplantation, viral hepatitis, liver cirrhosis, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, and biliary tract disorders. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact journals. She has been involved in medical teaching since the beginning of her career. Furthermore, she has been invited as a speaker at various international conferences, further solidifying her reputation as a leading expert in the field. Her work has been internationally recognized by receiving many prizes from well-known scientific organizations.

• Chapter 1: Definition and classification of short bowel syndrome.- Chapter 2: Epidemiology and survival of short bowel syndrome.- Chapter 3: Pathophysiology and anatomical considerations in short bowel syndrome.- Chapter 4: Humanistic burden of short bowel syndrome.- Chapter 5: Intestinal adaptation – mechanisms and therapy goals.- Chapter 6: Free water, electrolytes, and acid-base balance disturbances in short bowel syndrome.- Chapter 7: Refeeding syndrome: prevention, diagnosis, and treatment.- Chapter 8: Cholelithiasis and nephrolithiasis in short bowel syndrome.- Chapter 9: D-lactate encephalopathy in patients with short bowel syndrome.- Chapter 10: Metabolic bone disease in short bowel syndrome – diagnosis and management.- Chapter 11: Intestinal failure-associated liver disease.- Chapter 12: Insights into nutritional management of short bowel syndrome - nutritional assessment and diet considerations.- Chapter 13: Home parenteral nutrition in long-term intestinal failure.- Chapter 14: Long-term venous access for HPN: types, devices, and complications.-  Chapter 15: Monitoring and management of trace elements in short bowel syndrome.- Chapter 16: Enteral feeding and parenteral nutrition in short bowel syndrome – current recommendations and unmet needs.- Chapter 17: Drug pharmacokinetics and pharmacodynamics in short bowel syndrome – special considerations – Liliana Mirea Chapter 18: Antisecretory, antimotility and luminally active agents in the management of short bowel syndrome.- Chapter 19: Growth-stimulating effects of glucagon-like peptide-2, growth hormone and other agents.- Chapter 20: Surgical management of short bowel syndrome - ostomy, fistula, autologous gastrointestinal reconstruction.- Chapter 21: Intestinal transplantation in short bowel syndrome.- Chapter 22: Multidisciplinary approach in short bowel syndrome.- Chapter 23: Education of patients with short bowel syndrome.- Chapter 24: Future perspectives in short bowel syndrome - organoid-based tissue-engineered small intestine and SIC, xenotransplantation.

Anca Trifan, MD, PhD, FEBGH, FRCP (London), Professor of Gastroenterology and Internal Medicine, and Director of the Department of Internal Medicine of the “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, is also Head of the Institute of Gastroenterology and Hepatology, Iasi, Romania. Her research interests include inflammatory bowel disease, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, biliary tract disorders, and Clostridioides difficile infection. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact factor journals. She has been involved in medical teaching since the beginning of her career. She received many prizes from scientific organizations (e.g., Rising Stars in Gastroenterology awarded by UEG). She is a past president of the Romanian Society of Gastroenterology and Hepatology, a member of the Academy of Medical Sciences, a member of the European Board of Gastroenterology, an AGA fellow, and a member of the American Association for the Study of Liver Diseases.Carol Stanciu, MD, PhD, FRCP (London), Professor of Gastroenterology and Internal Medicine at the University of Medicine and Pharmacy “Gr. T. Popa,” Iasi, Fellow of the Academy of Medical Sciences, and Fellow of the Romanian Academy, Dr. Carol Stanciu (born May 17, 1937; Hasdat, Hunedoara, Romania) is one of the main founders of gastroenterology, diagnostic and therapeutic endoscopy in Romania. He graduated from the Faculty of Medicine, University of Medicine and Pharmacy “Gr.T.Popa” Iasi (1963) where he also received his PhD and DSc, and served as Assistant, Associate Professor, and Professor of the Department of Internal Medicine and Gastroenterology. He is the former Rector of the University of Medicine and Pharmacy “Gr.T.Popa” Iasi (1992-2004), Dean of the Faculty of Medicine (2004-2008), President of the Romanian Society of Endoscopy (1996-2000), President of the Romanian Society of Gastroenterology and Hepatology (2000-2008), and Chairman of the Ethics Committee of the World Organization of Gastroenterology (1994-2002). He has always been involved in all areas of academic life: medical training, especially therapeutic endoscopy, patient care, administrative work, and mentorship. His research interests include gastrointestinal motility, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, inflammatory bowel disease, biliary tract disorders, and Clostridium difficile infection. He has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of prestigious high-impact factor journals. He received many awards from the Romanian Presidency, French Presidency, WGO, Romanian Society of Gastroenterology and Hepatology, and many universities.Liana Gheorghe, MD, PhD, Professor of Gastroenterology and Hepatology, Department of Clinical Education of the Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, and Head of the 3rd Clinic of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. She is the President of the Romanian Association for Liver Disease, a highly active, non-profit medical association founded in 2018 aiming to disseminate science and the practice of hepatology in Romania. Also, she is the current president of the Romanian Society of Gastroenterology and Hepatology, an active member of the European Crohn's and Colitis Organization, the Romanian Crohn's and Colitis Club, and the European Society for Parenteral and Enteral Nutrition. Her research interests include inflammatory bowel disease, liver transplantation, viral hepatitis, liver cirrhosis, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, and biliary tract disorders. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact journals. She has been involved in medical teaching since the beginning of her career. Furthermore, she has been invited as a speaker at various international conferences, further solidifying her reputation as a leading expert in the field. Her work has been internationally recognized by receiving many prizes from well-known scientific organizations.

• Chapter 1: Definition and classification of short bowel syndrome.- Chapter 2: Epidemiology and survival of short bowel syndrome.- Chapter 3: Pathophysiology and anatomical considerations in short bowel syndrome.- Chapter 4: Humanistic burden of short bowel syndrome.- Chapter 5: Intestinal adaptation – mechanisms and therapy goals.- Chapter 6: Free water, electrolytes, and acid-base balance disturbances in short bowel syndrome.- Chapter 7: Refeeding syndrome: prevention, diagnosis, and treatment.- Chapter 8: Cholelithiasis and nephrolithiasis in short bowel syndrome.- Chapter 9: D-lactate encephalopathy in patients with short bowel syndrome.- Chapter 10: Metabolic bone disease in short bowel syndrome – diagnosis and management.- Chapter 11: Intestinal failure-associated liver disease.- Chapter 12: Insights into nutritional management of short bowel syndrome - nutritional assessment and diet considerations.- Chapter 13: Home parenteral nutrition in long-term intestinal failure.- Chapter 14: Long-term venous access for HPN: types, devices, and complications.-  Chapter 15: Monitoring and management of trace elements in short bowel syndrome.- Chapter 16: Enteral feeding and parenteral nutrition in short bowel syndrome – current recommendations and unmet needs.- Chapter 17: Drug pharmacokinetics and pharmacodynamics in short bowel syndrome – special considerations – Liliana Mirea Chapter 18: Antisecretory, antimotility and luminally active agents in the management of short bowel syndrome.- Chapter 19: Growth-stimulating effects of glucagon-like peptide-2, growth hormone and other agents.- Chapter 20: Surgical management of short bowel syndrome - ostomy, fistula, autologous gastrointestinal reconstruction.- Chapter 21: Intestinal transplantation in short bowel syndrome.- Chapter 22: Multidisciplinary approach in short bowel syndrome.- Chapter 23: Education of patients with short bowel syndrome.- Chapter 24: Future perspectives in short bowel syndrome - organoid-based tissue-engineered small intestine and SIC, xenotransplantation.

Anca Trifan, MD, PhD, FEBGH, FRCP (London), Professor of Gastroenterology and Internal Medicine, and Director of the Department of Internal Medicine of the “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, is also Head of the Institute of Gastroenterology and Hepatology, Iasi, Romania. Her research interests include inflammatory bowel disease, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, biliary tract disorders, and Clostridioides difficile infection. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact factor journals. She has been involved in medical teaching since the beginning of her career. She received many prizes from scientific organizations (e.g., Rising Stars in Gastroenterology awarded by UEG). She is a past president of the Romanian Society of Gastroenterology and Hepatology, a member of the Academy of Medical Sciences, a member of the European Board of Gastroenterology, an AGA fellow, and a member of the American Association for the Study of Liver Diseases.Carol Stanciu, MD, PhD, FRCP (London), Professor of Gastroenterology and Internal Medicine at the University of Medicine and Pharmacy “Gr. T. Popa,” Iasi, Fellow of the Academy of Medical Sciences, and Fellow of the Romanian Academy, Dr. Carol Stanciu (born May 17, 1937; Hasdat, Hunedoara, Romania) is one of the main founders of gastroenterology, diagnostic and therapeutic endoscopy in Romania. He graduated from the Faculty of Medicine, University of Medicine and Pharmacy “Gr.T.Popa” Iasi (1963) where he also received his PhD and DSc, and served as Assistant, Associate Professor, and Professor of the Department of Internal Medicine and Gastroenterology. He is the former Rector of the University of Medicine and Pharmacy “Gr.T.Popa” Iasi (1992-2004), Dean of the Faculty of Medicine (2004-2008), President of the Romanian Society of Endoscopy (1996-2000), President of the Romanian Society of Gastroenterology and Hepatology (2000-2008), and Chairman of the Ethics Committee of the World Organization of Gastroenterology (1994-2002). He has always been involved in all areas of academic life: medical training, especially therapeutic endoscopy, patient care, administrative work, and mentorship. His research interests include gastrointestinal motility, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, inflammatory bowel disease, biliary tract disorders, and Clostridium difficile infection. He has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of prestigious high-impact factor journals. He received many awards from the Romanian Presidency, French Presidency, WGO, Romanian Society of Gastroenterology and Hepatology, and many universities.Liana Gheorghe, MD, PhD, Professor of Gastroenterology and Hepatology, Department of Clinical Education of the Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, and Head of the 3rd Clinic of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. She is the President of the Romanian Association for Liver Disease, a highly active, non-profit medical association founded in 2018 aiming to disseminate science and the practice of hepatology in Romania. Also, she is the current president of the Romanian Society of Gastroenterology and Hepatology, an active member of the European Crohn's and Colitis Organization, the Romanian Crohn's and Colitis Club, and the European Society for Parenteral and Enteral Nutrition. Her research interests include inflammatory bowel disease, liver transplantation, viral hepatitis, liver cirrhosis, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, and biliary tract disorders. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact journals. She has been involved in medical teaching since the beginning of her career. Furthermore, she has been invited as a speaker at various international conferences, further solidifying her reputation as a leading expert in the field. Her work has been internationally recognized by receiving many prizes from well-known scientific organizations.

• Chapter 1: Definition and classification of short bowel syndrome.- Chapter 2: Epidemiology and survival of short bowel syndrome.- Chapter 3: Pathophysiology and anatomical considerations in short bowel syndrome.- Chapter 4: Humanistic burden of short bowel syndrome.- Chapter 5: Intestinal adaptation – mechanisms and therapy goals.- Chapter 6: Free water, electrolytes, and acid-base balance disturbances in short bowel syndrome.- Chapter 7: Refeeding syndrome: prevention, diagnosis, and treatment.- Chapter 8: Cholelithiasis and nephrolithiasis in short bowel syndrome.- Chapter 9: D-lactate encephalopathy in patients with short bowel syndrome.- Chapter 10: Metabolic bone disease in short bowel syndrome – diagnosis and management.- Chapter 11: Intestinal failure-associated liver disease.- Chapter 12: Insights into nutritional management of short bowel syndrome - nutritional assessment and diet considerations.- Chapter 13: Home parenteral nutrition in long-term intestinal failure.- Chapter 14: Long-term venous access for HPN: types, devices, and complications.-  Chapter 15: Monitoring and management of trace elements in short bowel syndrome.- Chapter 16: Enteral feeding and parenteral nutrition in short bowel syndrome – current recommendations and unmet needs.- Chapter 17: Drug pharmacokinetics and pharmacodynamics in short bowel syndrome – special considerations – Liliana Mirea Chapter 18: Antisecretory, antimotility and luminally active agents in the management of short bowel syndrome.- Chapter 19: Growth-stimulating effects of glucagon-like peptide-2, growth hormone and other agents.- Chapter 20: Surgical management of short bowel syndrome - ostomy, fistula, autologous gastrointestinal reconstruction.- Chapter 21: Intestinal transplantation in short bowel syndrome.- Chapter 22: Multidisciplinary approach in short bowel syndrome.- Chapter 23: Education of patients with short bowel syndrome.- Chapter 24: Future perspectives in short bowel syndrome - organoid-based tissue-engineered small intestine and SIC, xenotransplantation.