Sherlock's Diseases of the Liver and Biliary System

Anna S. Lok is a Professor of Internal Medicine, University of Michigan Medical Center. James S. Dooley is an Emeritus Reader in Medicine at the University of London Institute for Liver and Digestive Health (Royal Free Campus). Guadalupe Garcia-Tsao, MD, is Professor of Medicine, Department of Internal Medicine, Yale University School of Medicine and VA-Connecticut Healthcare System. Norah A. Terrault is Professor of Medicine and Chief Gastrointestinal and Liver Diseases Division University of Southern California. Palak Trivedi is Associate Professor and Consultant Hepatologist, Priory Hospital, Birmingham. Emmanouil Tsochatzis is a Professor of Hepatology and Honorary Consultant at the University College London Institute for Liver and Digestive Health, Royal Free Hospital.

• List of Contributors xviPreface to the Fourteenth Edition xxiiPreface to the First Edition xxiiiAcknowledgement xxiv1 Global Epidemiology and Burden of Liver Disease 1Markos Kalligeros and Zobair M. Younossi2 Anatomy and Function 14Pooja Khonde and Lei Zhao3 Liver Function in Health and Disease: Clinical Application of Liver Tests 33George Mells and Neliswa Gogela4 Jaundice and Cholestasis 53Richard J. Thompson and Jeremy S. Nayagam5 Biopsy of the Liver 70David Patch and Tu Vinh Luong6 Haemostasis in Liver Disease 83Jessica P.E. Davis, Stephen H. Caldwell, and Nicolas M. Intagliata7 Acute Liver Failure 99Shannan R. Tujios, Constantine Karvellas, and William M. Lee8 Hepatic Fibrogenesis 123Meena B. Bansal and Scott L. Friedman9 Non-invasive Assessment of Fibrosis and Cirrhosis 135Emmanuel A. Tsochatzis and Leon A. Adams10 Hepatic Cirrhosis and Portal Hypertension 156Yu Jun Wong and Juan G. Abraldes11 Ascites 172Anahita Rabiee and Guadalupe Garcia-Tsao13 Varices and Variceal Haemorrhage 256Dhiraj Tripathi and Dominique Thabut14 Palliative Care and Symptom-Based Management in Decompensated Cirrhosis 287Alan Noll and Shari Rogal15 Acute-on-Chronic Liver Failure and Critical Care Management of Cirrhosis 311Rajiv Jalan and Constantine J. Karvellas16 Vascular Disorders of the Liver and Extrahepatic Portal Hypertension 332Virginia Hernández-Gea17 Gallstones and Benign Biliary Disease 362Brian R. Davidson and George J. Webster18 Malignant Biliary Diseases 402Marina I. Crespo Cruz and John Bridgewater19 Fibropolycystic Liver Diseases and Congenital Biliary Abnormalities 416Mario Strazzabosco and Kathleen M. Loomes20 Primary Biliary Cholangitis 437Adriaan J. van der Meer and Palak J. Trivedi21 Primary and Secondary Sclerosing Cholangitis 468Natassia Tan and Gideon M. Hirschfield22 Autoimmune Hepatitis and Overlap Syndromes 489Ilkay Ergenc and Michael A. Heneghan23 Enterically Transmitted Viral Hepatitis: Hepatitis A and Hepatitis E 519Alexandra N. Willauer and Kenneth E. Sherman24 Hepatitis B 536Wen-Juei25 Hepatitis D 578Patrizia Farci and Grazia Anna Niro26 Hepatitis C 600Geoffrey Dusheiko and Mark W. Sonderup27 Drug-Induced Liver Injury 642Alisa Likhitsup and Robert J. Fontana28 Alcohol and the Liver 672Ewan Forrest29 Iron Overload States 694Heinz Zoller and Paul C. Adams30 Wilson Disease 716Eve A. Roberts and Karl Heinz Weiss31 Metabolic Dysfunction-Associated Steatotic Liver Disease 733Fasiha Kanwal and Vincent Wai-Sun32 Nutrition and Chronic Liver Disease 768Manuela Merli and Jaya Benjamin33 Pregnancy and Liver Conditions 782Monika Sarkar and Catherine Williamson34 The Liver in the Neonate, Infancy, and Childhood 801Rebecca Jeyaraj and Deirdre A. Kelly36 The Liver in Infections 875Alex Kew and Sanjay Bhagani37 Imaging of the Liver and Diagnostic Approach of Space-Occupying Lesions 911Neil H. Davies and Dominic Yu38 Benign Liver Tumours 923Ashley E. Stueck and Ian R. Wanless39 Primary Malignant Neoplasms of the Liver 938Daniel Q. Huang and Amit G. Singal40 Hepatic Transplantation: Pretransplant Management 965Lindsay Y. King and Carl L. Berg41 Hepatic Transplantation: Posttransplant Management 997Divya Ayyala-Somayajula and Norah A. TerraultIndex 1039