Sex Differences in the Human Brain, their Underpinnings and Implications

Dr. Savic’s group is a member of the Stockholm Brain Institute (SBI), a center at the Karolinska Institute for Cognitive and Computational Neuroscience. Her research focuses on the cognitive and emotional decline related to chronic stress as a recognized phenomenon and understanding the underlying mechanisms. They are applying several brain imaging techniques, including PET, to investigate how the human brain is affected by psychosocial stress, and explain the reported emotional and cognitive decline related to stress. The aim is to find biochemical markers of chronic psychosocial stress and develop new treatment strategies.

• Part I General overview1. Anatomical Sex Differences in adult brain (E Luders and A Toga)2. Anatomical Sex differences in the adolescent brain (T Paus) 3. Sex Influences in brain function with focus on Emotional Memory: The Burden of Proof has shifted. (L Cahill)4. Cerebral organization and function in relation to sexual orientation and Identity (I Savic, A Garcia-Falgueras and D Swaab)Part II The mechanisms behind sex dimorhism in the brain5. Genetics of brain sex differences (F Sanchesz and E Villain)6. The genetic and epigenetic interplay and of sex differences in the brain (I Qureshi and M Mehler) 7. Gene expression in neuroendocrine cells during the critical period for sexual differentiation of the brain (K Gagnidze, D Pfaff and J Mong)8. Neurosteroids – their impact on the human brain, and potential pharmacologic effects (S Reddy) Part III Clinical implications9. Sex, gender and pain (J Mogil and A Bailey) 10. The skewed sex distribution in affective disorders – a diagnostic, social or biological problem? (M Legato) 11. Empathizing, Systemizing, and the Extreme Male Brain theory of Autism (S Baron-Cohen)12. Gender and the injured brain (P Hurn)

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