This book constitutes the revised selected papers of the 16th Symposium and Summer School on Service-Oriented Computing, SummerSOC 2022, held in Hersonissos, Crete, Greece, in July 2022.The 8 full papers and 1 short paper presented in this volume were carefully reviewed and selected from 25 submissions. They were organized in topical sections as follows: Advanced Application Architecture; Data Science and Applications; and Quantum Computing.