Serpin Family

Proteins with Multiple Functions in Health and Disease

Inbunden, Engelska, 2015

AvMargarethe Geiger,Felix Wahlmüller,Margareta Furtmüller

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The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.

Produktinformation

Utgivningsdatum2015-11-25
Mått155 x 235 x 23 mm
Vikt738 g
FormatInbunden
SpråkEngelska
Antal sidor329
Upplaga15001
FörlagSpringer International Publishing AG
ISBN9783319227108

Tillhör följande kategorier

Kemi inom Naturvetenskap och teknik
Medicinsk utrustning och medicinska tekniker inom Medicin
Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Univ. Prof. Dr. Margarethe Geiger Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Wien Margarethe Geiger is a professor of vascular physiology at the Medical University of Vienna. Her research is focused on the role of non-inhibitory serine protease inhibitors in cell signaling. Dr. Margareta Furtmüller Department of Vascular Biology and Thrombosis Research, Med. Univ. Vienna, Schwarzspanierstrasse 17, 1090 Wien, email: margareta.furtmueller@meduniwien.ac.at Dr. Felix Wahlmüller Department of Vascular Biology and Thrombosis Research, Med. Univ. Vienna, Schwarzspanierstrasse 17, 1090 Wien, email: felix.wahlmueller@meduniwien.ac.at

1. Serpin Evolution and Genetics.- 2. Serpin Structure and Mechanism.- 3. New Serpins / New Functions of Serpins in Coagulation, Fibrinolysis, and Angiogenesis.- 4. Serpins in Development and Reproduction.- 5. Intracellular clade B serpins, intracellular functions of other serpins.- 6. Interaction of Serpins with Membrane-anchored Proteases.- 7. Serpins in Neurobiology.- 8. Serpins in Inflammation and Infectious Diseases.- 9. Cellular Proteostasis Systems Responsible for Orchestrating SERPIN Conformational Maturation and/or Disposal.- 10. SERPIN-related Diseases: Cellular Injury, Disease Modifiers, and Therapeutic Approaches.- 11. Serpins in Cancer.- 12. Non-mammalian Serpins.- 13. Serpins and Signal Transduction.- 14. Non-inhibitory serpins: structures and functions.- 15. (Patho)-physiology and/or novel functions of human serpins (in particular: vaspin) Serpins in animal models.