SE Hilary Russell, Senior Lecturer in Oncology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland. Peter A. Hall, Musgrave Professor of Pathology & Consultant Pathologist, Queens University Department of Pathology & The Royal Hospitals Trust,?Belfast, Northern Ireland. John R. Pringle, Professor of Genetics, Stanford University Medical Center, CA, USA.

• Contents Authors and Affiliations viiAn introduction to the septins 1Peter A. Hall, S. E. Hilary Russell and John R. PringleSection I Setting the scene 5Chapter 1 Origins and development of the septin field 7John R. PringleChapter 2 Evolution and conserved domains of the septins 35Michelle Momany, Fangfang Pan and Russell L. MalmbergSection II Septins in model systems 47Chapter 3 Biochemical properties and supramolecular architecture of septin hetero-oligomers and septin filaments 49Michael A. McMurray and Jeremy ThornerChapter 4 Yeast septins: a cortical organizer 101Yves BarralChapter 5 Septins in four model fungal systems: diversity in form and function 125Amy Gladfelter and Peter SudberyChapter 6 Septins in the metazoan model systems Drosophila melanogaster and Caenorhabditis elegans 147Christine M. Field, Amy Shaub Maddox, John R. Pringle and Karen OegemaSection III Septins in mammals 169Chapter 7 The genomics and regulation of the human septingenes 171S.E. Hilary RussellChapter 8 The functions of septins in mammals 187Carol D. Froese and William S. TrimbleChapter 9 Septin-interacting proteins in mammals 211Brandon E. Kremer and Ian G. MacaraChapter 10 Septin functions in the mammalian cytoskeleton 229Elias T. Spiliotis and W. James NelsonChapter 11 Septins and the synapse 247Jing Xue, Victor Anggono and Phillip J. RobinsonChapter 12 Septins and platelets 269Jerry Ware, Constantino Mart´ınez and Barbara ZiegerChapter 13 Septins and apoptosis 281Marie-Jeanne Carp and Sarit LarischChapter 14 Septins and human disease 295Peter A. Hall and Fern P. FingerChapter 15 Insight into septin functions from mouse models 319Makoto KinoshitaSection IV Envoi 337Chapter 16 Septins: 2008 and beyond 339Peter A. Hall, S.E. Hilary Russell and John R. PringleAppendix A Septin and septin-like sequences 343Michelle Momany, Fangfang Pan and Russell L. MalmbergAppendix B Mammalian septin nomenclature 351Peter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macara and John R. PringleAppendix C Septin meetings and workshops 355Peter A. Hall and John R. PringleIndex 361

"The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference." (Microbiology Today, May 2009)

SE Hilary Russell, Senior Lecturer in Oncology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland. Peter A. Hall, Musgrave Professor of Pathology & Consultant Pathologist, Queens University Department of Pathology & The Royal Hospitals Trust,?Belfast, Northern Ireland. John R. Pringle, Professor of Genetics, Stanford University Medical Center, CA, USA.

• Contents Authors and Affiliations viiAn introduction to the septins 1Peter A. Hall, S. E. Hilary Russell and John R. PringleSection I Setting the scene 5Chapter 1 Origins and development of the septin field 7John R. PringleChapter 2 Evolution and conserved domains of the septins 35Michelle Momany, Fangfang Pan and Russell L. MalmbergSection II Septins in model systems 47Chapter 3 Biochemical properties and supramolecular architecture of septin hetero-oligomers and septin filaments 49Michael A. McMurray and Jeremy ThornerChapter 4 Yeast septins: a cortical organizer 101Yves BarralChapter 5 Septins in four model fungal systems: diversity in form and function 125Amy Gladfelter and Peter SudberyChapter 6 Septins in the metazoan model systems Drosophila melanogaster and Caenorhabditis elegans 147Christine M. Field, Amy Shaub Maddox, John R. Pringle and Karen OegemaSection III Septins in mammals 169Chapter 7 The genomics and regulation of the human septingenes 171S.E. Hilary RussellChapter 8 The functions of septins in mammals 187Carol D. Froese and William S. TrimbleChapter 9 Septin-interacting proteins in mammals 211Brandon E. Kremer and Ian G. MacaraChapter 10 Septin functions in the mammalian cytoskeleton 229Elias T. Spiliotis and W. James NelsonChapter 11 Septins and the synapse 247Jing Xue, Victor Anggono and Phillip J. RobinsonChapter 12 Septins and platelets 269Jerry Ware, Constantino Mart´ınez and Barbara ZiegerChapter 13 Septins and apoptosis 281Marie-Jeanne Carp and Sarit LarischChapter 14 Septins and human disease 295Peter A. Hall and Fern P. FingerChapter 15 Insight into septin functions from mouse models 319Makoto KinoshitaSection IV Envoi 337Chapter 16 Septins: 2008 and beyond 339Peter A. Hall, S.E. Hilary Russell and John R. PringleAppendix A Septin and septin-like sequences 343Michelle Momany, Fangfang Pan and Russell L. MalmbergAppendix B Mammalian septin nomenclature 351Peter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macara and John R. PringleAppendix C Septin meetings and workshops 355Peter A. Hall and John R. PringleIndex 361

"The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference." (Microbiology Today, May 2009)

SE Hilary Russell, Senior Lecturer in Oncology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland. Peter A. Hall, Musgrave Professor of Pathology & Consultant Pathologist, Queens University Department of Pathology & The Royal Hospitals Trust,?Belfast, Northern Ireland. John R. Pringle, Professor of Genetics, Stanford University Medical Center, CA, USA.

• Contents Authors and Affiliations viiAn introduction to the septins 1Peter A. Hall, S. E. Hilary Russell and John R. PringleSection I Setting the scene 5Chapter 1 Origins and development of the septin field 7John R. PringleChapter 2 Evolution and conserved domains of the septins 35Michelle Momany, Fangfang Pan and Russell L. MalmbergSection II Septins in model systems 47Chapter 3 Biochemical properties and supramolecular architecture of septin hetero-oligomers and septin filaments 49Michael A. McMurray and Jeremy ThornerChapter 4 Yeast septins: a cortical organizer 101Yves BarralChapter 5 Septins in four model fungal systems: diversity in form and function 125Amy Gladfelter and Peter SudberyChapter 6 Septins in the metazoan model systems Drosophila melanogaster and Caenorhabditis elegans 147Christine M. Field, Amy Shaub Maddox, John R. Pringle and Karen OegemaSection III Septins in mammals 169Chapter 7 The genomics and regulation of the human septingenes 171S.E. Hilary RussellChapter 8 The functions of septins in mammals 187Carol D. Froese and William S. TrimbleChapter 9 Septin-interacting proteins in mammals 211Brandon E. Kremer and Ian G. MacaraChapter 10 Septin functions in the mammalian cytoskeleton 229Elias T. Spiliotis and W. James NelsonChapter 11 Septins and the synapse 247Jing Xue, Victor Anggono and Phillip J. RobinsonChapter 12 Septins and platelets 269Jerry Ware, Constantino Mart´ınez and Barbara ZiegerChapter 13 Septins and apoptosis 281Marie-Jeanne Carp and Sarit LarischChapter 14 Septins and human disease 295Peter A. Hall and Fern P. FingerChapter 15 Insight into septin functions from mouse models 319Makoto KinoshitaSection IV Envoi 337Chapter 16 Septins: 2008 and beyond 339Peter A. Hall, S.E. Hilary Russell and John R. PringleAppendix A Septin and septin-like sequences 343Michelle Momany, Fangfang Pan and Russell L. MalmbergAppendix B Mammalian septin nomenclature 351Peter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macara and John R. PringleAppendix C Septin meetings and workshops 355Peter A. Hall and John R. PringleIndex 361

"The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference." (Microbiology Today, May 2009)