Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects

Dr. Sangita Das is working as Newton International Fellow at Durham University, England, United Kingdom. She also works as a visiting professor in the Department of Energy Science in Mahatma Gandhi University, Kerala, India. She received her B. Sc. degree with honors in chemistry in 2008 from the University of Calcutta, Kolkata, West Bengal, India. She obtained her M. Sc. degree in chemistry with organic specialization in 2010 from the same university. She had qualified the all India (CSIR–JRF) NET, and then she joined “The Goswami Group,” Department of Chemistry, IIEST for her doctoral work under the supervision of Prof. Shyamaprosad Goswami. She got Ph.D. in 2016. Her areas of research interest include molecular recognition; design of fluorescence chemosensors; and characterization of fluorescence probe (detection of metal ions, anions, reactive oxygen species, nerve gas, and other environmentally hazardous species, etc.); aggregation-induced emission dyes and solid-state emitters, and synthesis of compounds with antidiabetic activity. She is now working as a Newton International Fellow in the United Kingdom. Her current research activities include the development of compounds as HDAC inhibitors, experimental and theoretical investigations of electronic structure of transition metal complexes with redox noninnocent ligands, and computational chemistry (DFT, TDDFT calculations). Sabu Thomas is a Professor and Director of the International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala, India. Professor Thomas is internationally recognized for his contributions to polymer science and engineering, with his research interests encompassing polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnology, and nano-biomedical sciences have significantly advanced the development of new materials for the automotive, space, housing, and biomedical fields.Dr. Partha Pratim Das is presently working as a postdoctoral researcher in Seoul National University, South Korea. He previously worked in the Institute of High-Pressure Mineral Physics and Chemistry, Yonsei University, Seoul, South Korea, as a postdoctoral researcher. He has completed both the B.Sc. (2008) and M.Sc. (2010) in chemistry from Calcutta University, India. He has received Ph.D. in science (chemistry) in 2016 from Jadavpur University, India. His working laboratories during Ph.D. are CSIR-CGCRI, Kolkata, and CSIR-NCL, Pune, India. His research area is focused on nanotechnology, synthesis, and structure–properties correlation studies of different multifunctional nanomaterials under various conditions for mainly clean and sustainable energy and environmental applications. He has published several high-impact papers in peer-reviewed journals. Moreover, his research works have been acclaimed in many national and international conferences and journal societies.

• Introduction1. Chemical warfare agents: An outlook on past and present technologies2. Metal-Organic-Framework Composite based rapid Self-Detoxifying Smart Textile Filters for Chemical-Warfare Agents3. Plasmonic Nanosensors for Chemical Warfare Agents4. Quantification of DCP (diethylchlorophosphate) for the recognition of organophosphorous chemical warfare agents5. Advances in gold nanoparticles for optical detection of nerve agents6. Functionalized two-dimensional photonic crystals for the detection of chemical warfare agents7. Optically advanced Carbon dots for sensing of harmful toxins8. Nano Materials in Organophosphate Sensing: Present and Future Perspective9. Smart hydrogel nanostructured sensor for detection of organophosphorus chemical warfare nerve agents10. Graphene based nanocomposites for detection of chemical messengers in nervous system11. Aptamer based approaches for sensing harmful synthetic and natural toxins12. MOFs derived nanoarchitectures for the detection of phenolic compounds13. Sensing of Phenol and Chlorophenols using Carbon Nanotubes Modified Glassy Carbon Electrode14. Nanotubes tethered laccase biosensor for sensing of chlorophenol substances15.  Use of organic compounds as Medical Products for the therapeutic treatment exposed to CW's agents16. An assessment of Chemical Warfare Agents in soils: Detection, Distribution and Ecotoxicology17. Assessment of the impact of chemical weapons disposal in the ocean according to international conventions18. Chemical Warfare: Unprecedented Environmental Threat19. Clinical Symptoms of Chemical Warfare Agents Toxicity including Mustards, Halogenated Oximes, Arsenicals, Toxins Poisoning20. Advances targeted therapy in toxicology and medical treatment of chemical warfare nerve agents21. The reversible inhibitors of acetylcholinestrerase as pre-treatment options against nerve agents intoxications22. Paraoxonase 1 as a potential prophylactic countermeasure against nerve agent poisoning23. Potential Alternative treatments and Routes of Administrations: Chemical Warfare Agents Poisoning24. Therapeutic Treatment of Nerve Agent toxicity 25. Carbon-nanomaterial modified molecularly imprinted polymers for the sensing of Organophosphorus simulants26. Carbon-nanomaterial modified recognition platforms for the sensing of organophosphorous simulants 27. Graphene-based nanocomposites for electrochemical sensing of Organophosphate triesters28. Synthesis of simulants of nerve agents for the assays of AChE inhibition29. Toxicological and Pharmacological Aspects of Organophosphorus Nerve Agents