This book constitutes the refereed proceedings of the 15th International Semantic Web Conference, ESWC 2018, held in Heraklion, Crete, Greece.The 48 revised full papers presented were carefully reviewed and selected from 179 submissions. The papers cover a large range of topics such as logical modelling and reasoning, natural language processing, databases and data storage and access, machine learning, distributed systems, information retrieval and data mining, social networks, and Web science and Web engineering.