Self-assembling Biomaterials

Molecular Design, Characterization and Application in Biology and Medicine

Inbunden, Engelska, 2018

Av Helena S. Azevedo, Ricardo M. P. da Silva

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Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field.

Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration.

Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community.

Explores both theoretical and practical aspects of self-assembly in biomaterials
Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials
Examines the use of dynamic self-assembling biomaterials

Produktinformation

Utgivningsdatum2018-04-19
Mått152 x 229 x undefined mm
Vikt1 100 g
FormatInbunden
SpråkEngelska
SerieWoodhead Publishing Series in Biomaterials
Antal sidor612
FörlagElsevier Science
ISBN9780081020159

Tillhör följande kategorier

Biomedicinsk teknik inom Medicin

Dr Helena S. Azevedo is a senior Lecturer in Biomedical Engineering and Biomaterials at Queen Mary University of London, UK. She has more than 15 years of research experience in biomaterials engineering and has developed significant work on the development of self-assembling biomaterials for biomedical applications. Dr. Ricardo da Silva has 13 years of research experience in the field of Biomaterials for Regenerative Medicine applications. His research work covers thermo-responsive polymers for drug delivery and cell sheet engineering, peptide self-assembly and supramolecular chemistry. He is a Research fellow at King’s College London, at the Centre for Craniofacial and Regenerative Biology, where he develops his research activities in self-assembling biomaterials and bone tissue engineering.

1. Self-assembling biomaterials: beginnings and progress over the past decadePart 1 Molecular building blocks for self-assembly2. Designing peptides for self-assembling biomaterials with controlled mechanical and biological performance3. Engineering silk fibroin for hydrogel self-assembly4. Elastin-like proteins – modular design for self-assembly5. Sweet building blocks for self-assembling biomaterials with molecular recognition6. Peptoid self-assembly and opportunities for biomaterials and biointerfaces7. Lipid bolaamphiphiles for fabricating membrane-mimetic biomaterials8. Self-assembling protein-DNA hybrid molecules as building blocks for complex biomaterials9. Biomaterials based on ureido-pyrimidinone (UPy) and benzene-1,3,5-tricarboxamide (BTAs) supramolecular polymers10. Self-assembling of biomaterials using host-guest chemistry Part 2 Unique properties of self-assembling biomaterials: blurring the frontiers between biomaterials and biology11. Adaptive supramolecular biomaterials through non-equilibrium self-assembly Part 3 Nanoscale characterization of self-assembling biomaterials12. Unveiling complex structure and dynamics in supramolecular biomaterials using super-resolution microscopy13. Probing local molecular dynamics in self-assembling systems with electron paramagnetic resonance (EPR) spectroscopy 14. Small angle X-ray scattering (SAXS) to study spatial arrangement in self-assembled biomaterials 15. Studying nanoscale interactions in self-assembling systems through molecular simulationsPart 4 Mechanisms of self-assembly: controlling driving forces and boundaries for self-assembly across scales16. Magnetic fields to align peptide assemblies and provide directionality in biomaterials17. Using confined environments to control the shape and size of assemblies18. Engineering dynamic self-assembling biomaterials at the interface19. Enzymatic mediated self-assemblyPart 5 Applications of self-assembling biomaterials20. Recreating stem cell niches using self-assembling biomaterials21. Bioactive self-assembling scaffolds for regenerative medicine22. Functionalization of self-assembling peptides for neural tissue engineering23. Self-assembling biomaterials as nanocarriers for the targeted delivery of drugs for cancer24. Self-assembling biomaterials for theranostic applications25. Self-assembling artificial enzymes: biomaterial therapies for metabolic diseases