This book introduces a real-time optimization (RTO) method based on the dynamic correlation integration (DCI) theory, which has the performances of modeling-free and self-adaptive model changes in real process. With this method, the implementation of RTO could be simplified in great deal comparing to traditional modeling way in many cases, and it especially benefits to the RTO of complex chemical reactions and the processes which are difficult to modeling.This book is applicable to real-time optimization theory researchers and practical application engineers for reference.