Selective Estrogen Receptor Modulators

A New Brand of Multitarget Drugs

Inbunden, Engelska, 2006

Av Antonio Cano, Joacquim Calaf i Alsina, Jose Luis Duenas-Diez, Joacquim Calaf I. Alsina, Joacquim Calaf I Alsina

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The concept of selective estrogen receptor modulators (SERMs) has emerged recently in modern medicine. Two main features, the evidence of the wide expression of estrogen receptors in organs and systems and the growing information on the determinants of estrogen action, have allowed the envisioning of compounds with "a la carte" estrogenic profiles. The availability of substances performing as agonists wherever the estrogenic action is beneficial and as antagonists where it is not, is becoming less of a dream than of a closer reality. This book is an up-to-date review of the principal basic mechanisms and the clinical data integrating the actual current knowledge on SERMs.

Produktinformation

Utgivningsdatum2006-06-13
Mått155 x 235 x 25 mm
Vikt729 g
FormatInbunden
SpråkEngelska
Antal sidor357
Upplaga2006
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783540242277

Tillhör följande kategorier

Basic Area.- Molecular Mechanisms of Estrogen Action in Target Tissues.- Clinical Pharmacology of Selective Estrogen Receptor Modulators (SERMs).- Action of Selective Estrogen Receptor Modulators (SERMs) Through the Classical Mechanism of Estrogen Action.- Cellular and Molecular Basis for Acute Nongenomically Mediated Actions of SERMs.- The Hypothalamus-Pituitary-Ovarian Axis as a Model System for the Study of SERM Effects: An Overview of Experimental and Clinical Studies.- Pure Antiestrogens.- Clinical Area.- Physiological Regulation of Bone Metabolism and Estrogen Agonism.- The Role of SERMs in the Treatment of Osteoporosis.- Cardiovascular Disease and SERMs.- SERMs and the Breast.- Endometrial Effects of SERMs.- Benign Gynecological Diseases and SERMs.- Other Clinical Effects of SERMs.- The Role of SERMs in the Management of Postmenopausal Women.

From the reviews of the first edition: "Sanchez and colleagues have assembled a timely addition to the clinician's library. Their book is an up-to-date synthesis of the basic mechanisms of action of estrogen and SERMs with a comprehensive analysis of receptor-mediated and non-receptor mediated events in target tissue. The sections on new SERMs and the clinical endocrinology of SERMs are very useful and will remain so for some time. The choice of basic and clinical topics makes for interesting reading. ... Overall, the book is well written and easy to read." (V. Craig Jordan, The New England Journal of Medicine, January, 2007)