Edited byPhilip J Smith BMedSci(Hons) BMBS MRCP(London)ST4 in Academic Clinical Fellow in Gastroenterology, London Deanery, London, UKManoj Ramachandran BSc(Hons) MBBS(Hons) MRCS(Eng) FRSC(Tr&Orth)Consultant Trauma and Orthopaedic Surgeon, Barts and The London NHS Trust, London, UK; Honorary Senior Lecturer, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, London, UKMarc A Gladman MBBS PhD MRCOG MRCS(Eng) FRCS(Gen Surg) UKCRC Clinical Lecturer in Surgery, Centre for Academic Surgery, Institute of Cell & Molecular Science, Barts and The London School of Medicine & Dentistry, London, UKAssociate EditorElizabeth A Owen MBBS BMedSci(Hons) MRCPCHST3 in Paediatrics, London Deanery, London, UK