Search for New Anticancer Drugs

• 1. Is there a future for the small molecule in developmental cancer chemotherapy?.- 2. The role of medicinal chemistry in the discovery of DNA-active anticancer drugs: from random searching, through lead development, to de novo design.- 3. In vitro systems for anticancer drug testing.- 4. Tumour hypoxia: challenges for cancer chemotherapy.- 5. Computer modelling and drug design.- 6. Differentiation inducers and their potential use in the treatment of acute myelogenous leukaemia.- 7. Angiosuppression.- 8. Preclinical evaluation and phase I trials.- 9. Evaluation: how should a new treatment be evaluated?.- 10. Oncogene-targeted antisense oligonucleotides: tools for genetic analysis or new anticancer drugs?.

' Overall, then, a well-edited and pretty up-to-date collection of interesting and useful articles. I would recommend it for a post-graduate seminar or debate on the medicinal chemistry of cancer. ' Annals of Oncology ' This book is recommended both for scientists engaged in anticancer drug development and for the interested outsider. In general it is well produced and, apart from a few exceptions, most of the chemical structures are refreshingly well drawn. The individual chapters are nicely sub-sectioned and all are comprehensively referenced to the primary literature; indeed some of the references have already been useful in our own work. ' Clinical Oncology, 5:4