This two-volume set constitutes selected papers presented during the Second International Conference on Science, Engineering Management and Information Technology, SEMIT 2023, held in Ankara, Turkey, during September 14–15, 2023.The 44 full papers and 2 short papers presented were carefully reviewed and selected from 409 submissions. The papers cover the following topics: Part I - Decision Analysis and Expert Systems; Machine Learning, Data Analysis and Computer Vision in Healthcare and Medicine; Smart Production, Transportation and Supply Chain Systems; Information Technology and Data Science in Industry.Part II - IoT, Blockchain, and Cyber Security in Complex Systems; Real-Time Data Analysis and Simulation in Engineering Systems; Digitalization and Artificial Intelligence in Manufacturing/ Service Industries; Soft Computing and Artificial Intelligence in Engineering Management and Marketing.