"I personally appreciate this volume because it represents genuine integrative biology--understanding system behavior from underlying principles and components. The viewpoint is frequently praised but seldom achieved in detail. This book is, in my opinion, an important contribution to quantitative biology and can be read and appreciated by both biologists and mathematicians."--Doody's"I personally appreciate this volume because it represents genuine integrative biology--understanding system behavior from underlying principles and components. The viewpoint is frequently praised but seldom achieved in detail. This book is, in my opinion, an important contribution to quantitative biology and can be read and appreciated by both biologists and mathematicians."--Doody's