Sarcoidosis

Donald N Mitchell MD FRCPHon Consultant PhysicianRoyal Brompton and University College HospitalsLondon, UKDavid R Moller MDProfessor of Medicine and DirectorSarcoidosis Clinic and Research ProgramDepartment of MedicineThe Johns Hopkins University School of MedicineBaltimore, Maryland, USAStephen G Spiro BSc MD FRCPProfessor of Respiratory Medicine and Honorary Consultant PhysicianUniversity College London and The Royal Brompton HospitalLondon, UKAthol Wells MBChB MD FRACP FRCP FRCRProfessor of Respiratory Medicine and Head of Interstitial Lung Disease UnitThe Royal Brompton HospitalLondon, UK

• Historical survey. Definition. Epidemiology Aetiology. Pathology. Immunology. Genetics. The radiology of the lungs and the pleura. Intervention and radiological procedures. Lung function. Endoscopy. DEXA scanning. Nuclear medicine imaging. ECG; Holter monitoring; exercise tests. The heart, pericardium, large and small vessels. The upper respiratory tract. Asthma/irritable airways. Pulmonary fibrosis. The liver and gastrointestinal tract. The spleen, blood and bone marrow. The nervous system. The kidneys and calcium metabolism. Psychiatric aspects. Sarcoidosis of the skin. Ocular changes. Bones, joints and skeletal muscles. Superficial lymphadenopathy. The endocrine glands. Sarcoid/HIV and AIDS. Sarcoid/relationship to neoplasm/chemotherapy [including isolated breast lesions]. Sarcoid/antibody deficiency syndromes. Concomitant or associated disorders. Pulmonary and extrapulmonary involvement by sarcoidosis in childhood. Diagnosis of sarcoidosis: history, physical examination, presumptive diagnosis without biopsy, sources of biopsy material, utilisation of investigations and imaging. Treatment of sarcoidosis:. Surgical investigation and management. Pulmonary/cardiac transplantation. Physiotherapy in sarcoidosis. Rehabilitation. Immunisation/vaccination. Future progress in investigations and management.