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This book looks at the role of proteases, which are enzymes that digest proteins, and the various roles that proteases play in the development of neurodegenerative diseases such as Alzheimer's disease, ALS, epilepsy, multiple sclerosis, as well as numerous other neuromuscular diseases.
Dr. Lajtha is the editor of the Journal of Neurochemical Research.
The Role of Proteolytic Eenzymes in Autoimmune Demyelinating Diseases: An Update.- Proteases in Demyelination.- Calcium Activated Neutral Proteinase in Demyelinating Diseases.- Papain-like Cysteine Proteases and Their Implications in Neurodegenerative Diseases.- The Role of the Calpain System in Neuromuscular Disease.- The Role of Calpain Proteolysis in Cerebral ischemia.- Calpain Isoforms in the Eye.- Metalloendopeptidase EC 3.4.24.15 in Neurodegeneration.- Cysteine Proteases, Synaptic Degeneration and Neuroodegenerative Disorders.- The Ubiquitin/Proteasome Pathway in Neurological Disorders.- Amyloid (Tace, Bace) and Presenilin Proteases Associated with Alzheimer’s Disease.- Caspases in Neurodegeneration.- Therapeutic Approaches with Protease Inhibitors in Neurodegenerative and Neurological Diseases.- Pathophysiology of Central Nervpis System Trauma: Proteolytic Mechanisms and Related Therapeutic Approaches.- Lysosomal Cysteine Proteases and Their Protein Inhibitor.- Proteases and Their Inhibitors in Gliomas.- Proteolysis of Mutant Gene Products are Key Mechanisms in Neurodegenerative Diseases.- Mammalian Proteinase Genes.