Role of Gut Microbiome in Neurodegenerative Disorders

Dr. Mukesh Kumar Yadav, is working as an Associate Professor at the Department of Microbiology, Central University of Punjab, Bathinda, Punjab, India. He has more than 15 years of research experience in the field of microbiology in general and microbial biofilms, host-pathogen interaction and endophytes in particular. In his laboratory, Dr. Yadav’s is working on microbial biofilms, antimicrobial resistance, pathogenesis and identification of novel pathways for the development of new antimicrobial/antibiofilm compounds. Dr. Yadav has published more than 74 research articles and received research grants from various funding agencies like, NRF Korea, Indian Council of Medical Research (ICMR), Department of Science and Technology (DST), Department of Biotechnology (DBT) and University Grant Commission (UGC). Dr. Balachandar Vellingiri mainly works on neurological diseases and analyzing its genetic impact. He is working on various neurological diseases to investigate the molecular mechanism and developing human induced pluripotent stem cells (HiPSCs), and generating patient-derived Brain organoids as a promising disease model for various neurological diseases because understanding the inside mechanism of neurological diseases is always a difficult task. Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. He is well-expertise in techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases. He has published over 100 research and review articles in various Internationally reputed SCI journals, 12 Book chapters and one book on Autism Spectrum Disorder.

• 1. Overview of Neurodegenerative Disorders2. Gut Microbiota and Neurological Diseases3. Gut-Brain Axis4. Gut-Brain Axis in Neurological Diseases5. Difference in the constitution of Gut Microbiota during Neurodegenerative Disorders6. Gut Metabolites in Neurodegenerative Diseases7. Influence of Gut Microbiota on Cerebellum8. Influence of Gut Microbiota on Hippocampus9. Influence of Gut Microbiota on Axonal Cells of the brain10. Mechanistic action of Gut Microbiota on Glial cells11. Gut as a second brain- Largest producer of serotonin12. Gradual Shift of gut microbial Population as a diagnostic marker for Neurodegenerative disorders13. Gut metabolites – effective biomarker for Neurodegenerative disorder14. Protocol – Isolation of Gut Microbiome from Faecal sample15. Gut metabolites isolation from Blood16. Metagenomics and sequence analysis17. Computer aided detection method18. Existing therapeutic options to alter gut composition in Neurodegenerative Disorders19. Dietary and Gut microbiome20. Ongoing clinical trials21. Ethical hurdles for the treatment of a disease focusing Gut Microbiota22. Futuristic therapies in pipeline for the betterment of Neurodegenerative Disorders