Rodent Models of Neurodegenerative Disease

Rodent Models of Neurodegenerative Disease explores neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Lewy body disease, and prion disease which represent some of the most complex and devastating challenges in neuroscience. With rising prevalence in aging populations worldwide, these disorders place immense burdens on patients, families, and healthcare systems. This comprehensive volume, Rodent Models of Neurodegenerative Disease, provides an in-depth examination of the utility, strengths, and limitations of rodent models in unraveling the molecular, cellular, and behavioral aspects of neurodegeneration. Organized by disease, each chapter explores both genetic and non-genetic models, highlighting their relevance to human pathology, translational value, and contributions to therapeutic discovery.Key features of this book include the following:• Detailed coverage of rodent models for major neurodegenerative diseases.• Critical analysis of disease mechanisms, from protein aggregation and mitochondrial dysfunction to neuroinflammation and synaptic loss.• A dedicated chapter on behavioral assays, bridging molecular pathology with motor, cognitive, and social outcomes. Insights into the translational challenges of preclinical research and its role in shaping future therapies. With contributions from leading neuroscientists, this book serves as a valuable reference for researchers, graduate students, and professionals in neuroscience, neurology, pharmacology, and related fields. Whether for experimental design, model selection, or therapeutic evaluation, it provides an essential guide for advancing neurodegenerative disease research.About the Editors:Dr. Pegah Javadpour, PhD, is Assistant Professor of Medical Physiology at the Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Her research focuses on mitochondrial dysfunction, oxidative stress, and neuroinflammation in neurodegenerative disorders, particularly Parkinson’s and Alzheimer’s diseases. She has a special interest in mitochondria-targeted therapeutic strategies, including mitochondrial transplantation therapy (mitotherapy), as potential treatments for these conditions.Dr. Rasoul Ghasemi, PhD, is Associate Professor of Physiology in the Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. His research explores the neurophysiology of learning and memory, with emphasis on insulin signaling, hippocampal function, neuroinflammation, oxidative stress, and neuroprotection in neurodegenerative diseases. He has published extensively on the cellular and molecular mechanisms underlying brain resilience and pathology.