This book constitutes the refereed proceedings of the 8th International Conference on Reversible Computation, RC 2016, held in Bologna, Italy, in July 2016. The 18 full and 5 short papers included in this volume were carefully reviewed and selected from 38 submissions. The papers are organized in topical sections named: process calculi; reversible models; programming languages; quantum computing; quantum programming; circuit theory; and syntheses.