This book constitutes the refereed proceedings of the 14th International Conference on Reversible Computation, RC 2022, which was held in Urbino, Italy, during July 5-6, 2021.The 10 full papers and 6 short papers included in this book were carefully reviewed and selected from 20 submissions.  They were organized in topical sections named: Reversible and Quantum Circuits;  Applications of quantum Computing; Foundations and Applications.