Retinoic Acids in Cancer Therapy

Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery, Volume 21 offers a detailed exploration of how All Trans Retinoic Acid (ATRA) functions to kill cancer cells, as well as the survival mechanisms of certain cells when treated with this drug. This comprehensive book delves into the specific cell pathways and compartments that are involved in the action of retinoic acids (RAs) in inhibiting cell proliferation across various cancers, providing invaluable insights for continued research and improved therapeutic approaches in oncology.

The book comprises 16 chapters that address the molecular structure and biological properties of ATRA, elucidate the mechanisms of resistance to ATRA, and evaluate its efficiency in treating seven different cancers. Additionally, it discusses strategies to enhance ATRA cancer treatment and offers future perspectives on its applications. As a vital resource for health professionals, researchers, and students alike, this volume aims to expand the collective understanding of ATRA's therapeutic potential and inspire the development of new, more effective cancer treatments.

• Identifies the most important pathways, including in apoptosis (intrinsic, extrinsic), in an informative and concise schematic way
• Provides new perspectives on understanding the impact of autophagy in RAs induced apoptosis and how targeting autophagy could improve RAs induced apoptosis in different cancers
• Discusses strategies to change the fate of cancer stem cells and target them with RAs to improve their effectiveness