Rethinking Clinical Research

Methodology and Ethics

Häftad, Engelska, 2025

AvKaren B. Schmaling,Robert M. Kaplan

679 kr

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This book provides a comprehensive analysis of biases inherent in contemporary clinical research, challenging traditional methodologies and assumptions. Aimed at students, professionals, and science enthusiasts, the book delves into fundamental principles, research tools, and ethics. It is organized in three sections: The first section covers fundamentals including framing clinical research questions, core research tools, and clinical research ethics. The second section discusses topics relevant to clinical research, organized according to their relevance in the development of a clinical study. Chapters within this section examine the strengths and limitations of traditional and alternative methods, ethical issues, and patient-centered consequences. The third section presents four in-depth case examples, illustrating issues across diverse health conditions and treatments: gastroesophageal reflux disease, hypercholesterolemia, screening for breast cancer, and depression. This examination encourages readers to critically evaluate the methodologies and assumptions underlying clinical research, promoting a nuanced understanding of evidence production in the health sciences.

Produktinformation

Utgivningsdatum2025-03-20
Mått229 x 150 x 23 mm
Vikt532 g
FormatHäftad
SpråkEngelska
Antal sidor367
FörlagCambridge University Press
ISBN9781009391726

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Karen B. Schmaling is a professor of clinical psychology at Washington State University. She has over 150 publications that have been cited over 12,000 times. Her research has been supported by the US National Institutes of Health and National Science Foundation. Robert M. Kaplan is a senior scholar at Stanford University's Clinical Excellence Research Canter. He previously served as Associate Director of the National Institutes of Health, and as Chief Science Officer for the Agency for Healthcare Research and Quality. Kaplan was elected to US National Academy of Medicine in 2005.

Introduction; Part I. Fundamentals: 1. 'Can it work? Does it work? Is it worth it?'; 2. Core research tools; 3. Clinical research ethics; Part II. Rethinking research: 4. Asking the right questions; 5. Bias in randomized controlled trials; 6. Is bigger always better?: On sample size, statistical significance, and big data; 7. Achieving transparency; 8. Understanding and restraining study costs; 9. Implementation: getting the right interventions to market; 10. Health outcomes: a comprehensive approach; 11. Confronting the crises in peer review and academic publishing; 12. Ontologies: promoting a shared scientific mission; Part III. Case studies: 13. Case study: treating gastroesophageal disease with Omeprazole; 14. Case study: statin therapy for primary prevention of heart disease; 15. Case study: cancer screening; 16. Case study: antidepressant medications; 17. Conclusions and recommendations.

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