Restless Legs Syndrome

William G. Ondo

• Overview of Sleep.  The Brain's Dopamine Systems.  Circadian Physiology.  Systemic Iron Regulation.  The Physiology of RLS.  Progress in the Animal Modeling of RLS.  Pathology of RLS.  Genetics of RLS.  Consequences of Sleep Deprivation.  Diagnostic Criteria and Differential Diagnosis.  Occurrence of RLS.  Childhood-Onset RLS.  Periodic Limb Movement of Sleep.  Quality of Life in RLS.  Patient Perspectives.  Iron Deficiency-Associated RLS.  Renal Failure.  Neuropathy/Myelopathy.  Pregnancy.  Parkinson's Disease.  Iatrogenic RLS.  Other RLS Associations.  Treatment Overview.  Dopaminergic Treatment of RLS.  Dopaminergic Augmentation.  Opioid Treatment of RLS.  Iron Therapy in RLS.  Other Therapies in RLS.  Future Directions.