Resistance to Targeted Therapies Against Adult Brain Cancers

Amanda Tivnan, PhD, is Senior Postdoctoral Research Fellow, Department of Physiology and Medical Physics, The Royal College of Surgeons, Dublin, Ireland.

• Targeted therapies in gliomas: An overview.- Targeting chemotherapy resistance in glioblastoma through modulation of ABC transporters.- Resistance of Glioblastomas to Radiation Therapy.- The blood-brain barrier in glioblastoma multiforme: Pathology and therapeutic implications.- Resistance of brain tumours to small-molecule targeted therapies: lessons from various cancer types.- Drug repurposing to circumvent chemotherapy resistance in brain tumours.- Small molecule inhibitors in glioblastoma: Key pathways and resistance mechanisms.- Imaging Targeted Therapy Response and Resistance in Glioblastoma.- Drug Resistance in Malignant Meningiomas.- Recurrence of Low-Grade Glioma - Have the Targeted Therapies Improved for Better Outcomes?.- Host-Tumor Interactions in Brain Cancer Metastasis Leading to Drug Resistance.

“This is a complete monograph on the molecular and cell biology of 'brain tumors' resistant mechanisms. The book discusses chemotherapy and radiotherapy of brain malignancies including gliomas, ependynomas, and meningiomas. … I highly recommend this book as a reference and research tool for neurosurgeons, oncologists, neurologists, residents, and students.” (Joseph Grenier, Amazon.de, May, 2018)