Resistance to Targeted ABC Transporters in Cancer

This critical review volume explores the theme of ABC transporters in the context of basic cancer research and itsrole in drug-resistant tumors. Thechapters providedcomplement basic research by includinginvestigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapyand the field has been moving rapidly in terms of determining the mechanisms for blockingABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volumecovers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is alsodiscussed.