This book constitutes the refereed proceedings of the 22nd International Conference on Relational and Algebraic Methods in Computer Science, RAMiCS 2026, held in Będlewo, Poland, during April 7–10, 2026.The 18 full papers included in this book were carefully reviewed and selected from 23 submissions. RAMiCS 2026 topics range from mathematical foundations to applications as conceptual and methodological tools in computer science and beyond.solutions.