Rejuvenation and Longevity

Khachik K. Muradian, DSc, PhD, is Chief Scientific Researcher and leads the Group "Experimental Life Span Extension" at the Department of the Biology of Aging and Life Span Extension, Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine. Having published over 100 articles in peer-reviewed journals, his research focuses on radical life span extension and rejuvenation and is currently working on cell and metabolic reprogramming as a tool for life span extension and treatment of age-related pathology. He is the author of the first fundamental work in the field of Life Span Prolongation. He has published over 10 book chapters on the role of apoptosis, environment, metabolism, antioxidants and induced cellular reprogramming on life span and longevity. Since 2007 he is a member of the Advisory Board of the Lifeboat Foundation: Safeguarding Humanity and has chaired numerous meetings relating to aging, longevity and gerontology. Vadim E. Fraifeld, MD, PhD is Professor at the Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences. He leads the Lab for the Biology of Aging and the Research Group “Biological Determinants of Aging, Longevity, and Age-related Diseases” which includes four labs at the Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev (BGU), Beer-Sheva, Israel. He is as well the Chief Scientific Researcher of the Department of Biology of Aging and Experimental Life Span Extension, Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine. He is the coordinator and lecturer of three courses on the biology of aging: Introductory, Basic, and Advanced. His major research interests focus on the systems biology of aging, longevity, and age-related diseases; cell reprogramming; cellular senescence; stem cell biology; wound healing and fibrosis. A top priority of his research interests is searching for determinants of life span and the ways of its extension and achieving healthy longevity. He has published over 90 papers and is an active editorial board member of 10 peer-reviewed journals. He was a Chief Organizer of the 8th European Congress of Biogerontology.Since 1980s, the authors have tightly co-operated on problems of longevity, life span extension and rejuvenation.

• Introduction to optimistic gerontology.- The origin of life, immortality, and aging.- Cellular learning, decision-making, and rejuvenation.- Sporulation, meiosis and rejuvenation.- Longevity secrets of the three marine beauties—sponges, corals and sea anemones.- Metazoans who live longer than Jeanne Calment.- Transposable elements and rejuvenation of genome.- Embryonic stem cells and the ‘last-minute’ correction.- Muse cells and VSEL stem cells in longevity and rejuvenation.- The paradox of the adult stem cells: Relevance to aging and rejuvenation.- Biological age can be moved in both directions.- Rejuvenation is on its way.