Regulatory Mechanisms of Striated Muscle Contraction

• Historical Aspects.- Biological Actions of Calcium.- Professor Ebashi’s Journey Toward the Discovery of Troponin: A Personal Recollection.- Highlights of the History of Calcium Regulation of Striated Muscle.- Regulation by Troponin and Tropomyosin.- Troponin: Structure, Function and Dysfunction.- From the Crystal Structure of Troponin to the Mechanism of Calcium Regulation of Muscle Contraction.- Ca Ion and the Troponin Switch.- Disposition and Dynamics: Interdomain Orientations in Troponin.- Structural Basis for Calcium-Regulated Relaxation of Striated Muscles at Interaction Sites of Troponin with Actin and Tropomyosin.- Tropomyosin: Regulator of Actin Filaments.- Tropomyosin and Troponin Cooperativity on the Thin Filament.- Conformational Changes in Reconstituted Skeletal Muscle Thin Filaments Observed by Fluorescence Spectroscopy.- Calcium Structural Transition of Troponin in the Complexes, on the Thin Filament, and in Muscle Fibres, as Studied By Site-Directed Spin-Labelling EPR.- Crystal Structures of Tropomyosin: Flexible Coiled-Coil.- C. Elegans Model for Studying Tropomyosin and Troponin Regulations of Muscle Contraction and Animal Behavior.- Structural and Functional Analysis of Troponins from Scallop Striated and Human Cardiac Muscles.- Regulation in Cardiac Muscle and Disorders.- Cooperativity in the Regulation of Force and the Kinetics of Force Development in Heart and Skeletal Muscles.- Heart Failure, Ischemia/Reperfusion Injury and Cardiac Troponin.- Troponin Mutations in Cardiomyopathies.- Molecular Pathogenic Mechanisms of Cardiomyopathies Caused by Mutations in Cardiac Troponin T.- Cardiac Troponin Levels as a Preferable Biomarker of Myocardial Cell Degradation.- Regulation by Myosin.- Regulation by Myosin: How Calcium Regulates Some Myosins, Past andPresent.- Calcium Inhibition of Physarum Myosin as Examined by the Recombinant Heavy Mero-Myosin.- Excitation-Contraction Coupling and Disorder.- Calcium-Induced Release of Calcium From the Sarcoplasmic Reticulum.- Dysregulation of the Gain of CICR Through Ryanodine Receptor1 (RyR1): The Putative Mechanism Underlying Malignant Hyperthermia.- Ion Pumping by Calcium ATPase of Sarcoplasmic Reticulum.- Regulation of Cell Functions by Ca2+ Oscillation.- Molecular Mechanisms of Muscle Contraction.- Evidence About the Structural Behaviour of Myosin Crossbridges During Muscle Contraction.- Structural Alterations of Thin Actin Filaments in Muscle Contraction by Synchrotron X-ray Fiber Diffraction.- Regulation of Muscle Contraction by Ca2+ and ADP: Focusing on the0 Auto-Oscillation (SPOC).- Muscle Contraction Mechanism Based on Actin Filament Rotation.- On the Walking Mechanism of Linear Molecular Motors.- Modeling of the F-Actin Structure.

From the reviews: "This book comprehensively covers the accumulated knowledge of the regulatory mechanisms controlling striated muscle contraction. The organization and presentation of basic research findings ... result in an excellent book that accurately represents the history and current state of the field. ... It is written for practitioners of basic and clinical research in the field of striated muscle function and dysfunction. ... It contains a wealth of information that is organized in an excellent manner, allowing the reader to quickly locate areas of interest and relevance." (Kristin L. Gosselink, Doody's Review Service, September, 2008)