Editors:Nariyoshi ShinomiyaDepartment of Integrative Physiology and Bio‐Nano Medicine, National Defense Medical College, Tokorozawa, JapanHiroaki KataokaDepartment of Pathology, University of Miyazaki, Miyazaki, JapanQian XieDepartment of Biomedical Sciences, East Tennessee State University, Johnson City,TN, USA

• 1. Regulation of microRNA expression by growth factors.- 2. TGF-b signaling and epithelial mesenchymal transition.- 3. Molecular designing of small molecule inhibitor for apoptotic pathways.- 4. Using genetically engineered mouse models to study Wnt signaling in bone development and disease.- 5. Glucose signaling and glycolysis.- 6. The interplay of tumor suppressor p53 with hypoxia-inducible factor-1 (HIF-1) at the crossroad between hypoxia-mediated cell survival and death.- 7. Role of G protein-coupled receptor signaling on the proliferation and differentiation of multipotent stem cells.- 8. Met-KO and carcinogenesis9.  Clinical impact of MET pathway in cancer.- 10. Pericellular proteolytic activation of growth factors.

Editors:Nariyoshi ShinomiyaDepartment of Integrative Physiology and Bio‐Nano Medicine, National Defense Medical College, Tokorozawa, JapanHiroaki KataokaDepartment of Pathology, University of Miyazaki, Miyazaki, JapanQian XieDepartment of Biomedical Sciences, East Tennessee State University, Johnson City,TN, USA

• 1. Regulation of microRNA expression by growth factors.- 2. TGF-b signaling and epithelial mesenchymal transition.- 3. Molecular designing of small molecule inhibitor for apoptotic pathways.- 4. Using genetically engineered mouse models to study Wnt signaling in bone development and disease.- 5. Glucose signaling and glycolysis.- 6. The interplay of tumor suppressor p53 with hypoxia-inducible factor-1 (HIF-1) at the crossroad between hypoxia-mediated cell survival and death.- 7. Role of G protein-coupled receptor signaling on the proliferation and differentiation of multipotent stem cells.- 8. Met-KO and carcinogenesis9.  Clinical impact of MET pathway in cancer.- 10. Pericellular proteolytic activation of growth factors.

Editors:Nariyoshi ShinomiyaDepartment of Integrative Physiology and Bio‐Nano Medicine, National Defense Medical College, Tokorozawa, JapanHiroaki KataokaDepartment of Pathology, University of Miyazaki, Miyazaki, JapanQian XieDepartment of Biomedical Sciences, East Tennessee State University, Johnson City,TN, USA

• 1. Regulation of microRNA expression by growth factors.- 2. TGF-b signaling and epithelial mesenchymal transition.- 3. Molecular designing of small molecule inhibitor for apoptotic pathways.- 4. Using genetically engineered mouse models to study Wnt signaling in bone development and disease.- 5. Glucose signaling and glycolysis.- 6. The interplay of tumor suppressor p53 with hypoxia-inducible factor-1 (HIF-1) at the crossroad between hypoxia-mediated cell survival and death.- 7. Role of G protein-coupled receptor signaling on the proliferation and differentiation of multipotent stem cells.- 8. Met-KO and carcinogenesis9.  Clinical impact of MET pathway in cancer.- 10. Pericellular proteolytic activation of growth factors.