Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover. Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

• 244 Nuclear Receptor Coactivators245 Corepressors in Mediating Repression by Nuclear Receptors246 Steroid Hormone Receptor Signaling247 Role of COUP-TFII in Congenital Diaphragmatic Hernia248 Nuclear Receptors in Drosophila melanogaster249 JAK-STAT Signaling 250 FOXO Transcription Factors: Key Targets of the PI3K-Akt Pathway 251 The Multi-gene Family of Transcription Factor AP-1252 NF-KB: a Key Integrator of Cell Signaling253 Transcriptional Regulation via the cAMP Responsive Activator CREB254 The NFAT Family: Structure, Regulation and Biological Functions255 Ubiquitination/Proteasome256 The SMADs257 Complexity of Stress Signaling258 Signal Transduction in the Escherichia coli SOS Response259 Oxidative Stress and Free Radical Signal Transduction260 Screening Approaches to Identify Genes Required for DNA Double-Strand Break 261 Radiation Responses in Drosophila262 Double-strand Break Recognition and its Repair by Non-homologous End Joining 263 ATM-Mediated Signaling Defends the Integrity of the Genome264 Signaling to the p53 Tumor Suppressor through Pathways 265 The p53 Master Regulator and Rules of Engagement with Target Sequences266 Nuclear and Cytoplasmic Functions of Abl Tyrosine Kinase 267 Radiation-induced Cytoplasmic Signaling268 The Heat-Shock Response and the Stress of Misfolded Proteins269 Hypoxia-Mediated Signaling Pathways270 Regulation of mRNA Turnover by Cellular Stress271 Oncogenic Stress Responses 272 Ubiquitin and FANC Stress Responses273 Stress and g -H2AX274 Translational Control by Amino Acids and Energy275 Translation Control and Insulin Signaling 276 ER and oxidative stress: Implications in disease277 Regulation of mRNA Turnover278 Signaling to Cytoplasmic Polyadenylation and Translation279 Translational Control in Invertebrate Development280 The Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death281 Signaling Pathways that Mediate Translational Control of Ribosome Recruitment 282 The SWI/SNF and RSC Nucleosome Remodeling Complexes283 ISWI Chromatin Remodeling Complexes284 The INO80 Chromatin Remodeling Complex285 Histone Acetylation Complexes286 Regulation of Histone Deacetylase Activities and Functions by Phosphorylation and 287 Histone Methylation: Chemically Inert But Chromatin Dynamic288 Histone Phosphorylation: Chromatin Modifications 289 Histone Variants: Signaling or Structural Modules? 290 Silent Chromatin Formation and Regulation in the Yeast Saccharomyces cerevisiae291 Gene Silencing and Chromatin Modification by Polycomb Complexes 292 Histone Ubiquitination293 Chromatin-mediated Control of Gene Expression in Innate Immunity and Inflammation

"In order to keep researchers and students up to date on developments in the field, 55 articles were selected and reprinted from the 2008 second edition of the ‘Handbook of Cell Signaling’ on the transcriptional regulation and the function of nuclei and other subcellular organelles in signaling activities. After an overview, they cover nuclear signaling in transcription, chromatic remodeling, and stress response; signaling to and from intracellular compartments; and cell cycle and cell death signaling. This is one of four volumes of such reprints, called the Cell Signaling Collection."--Reference and Research Book News