Regulation of Cellular Systems

Inbunden, Engelska, 1996

AvReinhart Heinrich,Stefan Schuster

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This work deals with some problems and approaches in cellular systems and covers a range of cell types and cell systems, including nerve cells. It should be of interest to the theoretical and mathematical biology community; all cell biologists interested in modelling; and individuals interested in evolutionary issues as they bear on cellular metabolic models.

Produktinformation

Utgivningsdatum1996-08-31
Mått152 x 229 x 27 mm
Vikt725 g
FormatInbunden
SpråkEngelska
Antal sidor372
Upplaga1996
FörlagChapman and Hall
ISBN9780412032615

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Cellbiologi inom Naturvetenskap och teknik

1. Introduction.- 2. Fundamentals of Biochemical Modeling.- 2.1. Balance Equations.- 2.2. Rate Laws.- 2.3. Steady States of Biochemical Networks.- 2.4. Metabolic Oscillations.- 3. Stoichiometric Analysis.- 3.1. Conservation Relations.- 3.2. Admissible Steady-State Vectors and the Null-Space.- 3.3. Thermodynamic Aspects.- 4. Time Hierarchy in Metabolism.- 4.1. Time Constants of Metabolic Processes.- 4.2. The Quasi-Steady-State Approximation.- 4.3. The Rapid-Equilibrium Approximation.- 4.4. Modal Analysis.- 5. Metabolic Control Analysis.- 5.1. Basic Definitions.- 5.2. A Systematic Approach.- 5.3. Theorems of Metabolic Control Analysis.- 5.4. Control Analysis of Various Systems.- 5.5. Time-Dependent Control Coefficients.- 5.6. Are Control Coefficients Always Parameter Independent?.- 5.7. Normalized Versus Non-normalized Coefficients.- 5.8. Analysis in Terms of Variables Other Than Concentrations and Fluxes.- 5.9. A Second-Order Approach.- 5.10. Metabolic Regulation from the Viewpoint of Control Analysis.- 5.11. Control Within and Between Subsystems.- 5.12. Modular Approach.- 5.13. Flux Control Insusceptibility.- 5.14. Control Exerted by Elementary Steps in Enzyme Catalysis.- 5.15. Control Analysis of Metabolic Channeling.- 5.16. Comparison of Metabolic Control Analysis and Power- Law Formalism.- 5.17. Computational Aspects.- 6. Application of Optimization Methods and the Interrelation with Evolution.- 6.1. Optimization of the Catalytic Properties of Single Enzymes.- 6.2. Optimization of Multienzyme Systems.- 6.3. Optimal Stoichiometrics.- References.

...a must, if we want to obtain the unification of all the theories in matter of the regulation of complex cellular systems. - Cellular and Molecular Biology; ...a must, if we want to obtain the unification of all the theories in matter of the regulation of complex cellular systems. - Cellular and Molecular Biology; For specialists already concerned with the kinetic behaviour of the multi-enzyme systems, this is the book they need to have- Bulletin of Mathematical Biology