Radical Brook Rearrangement

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Inbunden, Engelska, 2026

2 139 kr

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In-depth monograph presenting innovative radical methodologies in the Brook rearrangement and their utility in organic synthesis Radical Brook Rearrangement chronicles the evolution of radical Brook rearrangements, synthesizes recent advances in the field, and outlines future research directions. The book focuses on three key reactive intermediates—α-siloxyl radicals, siloxycarbenes, and silenes — providing detailed analyses of their generation methods, substrate scope, mechanistic insights, and synthetic applications, along with practical experimental protocols. Readers will find insights on alkoxy radical generation, photocatalytic systems, and the selection of radical/carbene acceptors. This book deliberately focuses on radical processes, excluding anionic pathways. Written by a team of highly qualified researchers in the field, Radical Brook Rearrangement includes information on: Generation of siloxycarbenes for metal siloxycarbene reaction, with information on minooxycarbene reactionsGeneration of siloxycarbenes for nucleophilic addition reaction, covering aldehydes and ketones as electrophiles and other electrophilic reagentsGeneration of α-siloxy silyl radicals with (TMS)3SiOH, covering photoredox reactions and metallaphotoredox reactions with (TMS)3SiNHAdGeneration of α-siloxy radicals with α-silyl alcohol, covering metal-free, metal-catalyzed, photocatalyzed, and electrophotocatalyzed reactionsContaining cutting-edge research discoveries on the subject, Radical Brook Rearrangement is an essential reference for chemists across specializations, materials scientists, and professionals in the pharmaceutical industry.

Produktinformation

Utgivningsdatum2026-03-04
Mått170 x 244 x undefined mm
FormatInbunden
SpråkEngelska
Antal sidor288
FörlagWiley-VCH Verlag GmbH
ISBN9783527354634

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Xiao Shen is Professor at the Institute for Advanced Studies, Engineering Research Centre of Organosilicon Compounds & Materials, Ministry of Education, Wuhan University, China. He is a member of the Youth Editorial Board of Chinese Chemical Letters. Yunxiao Zhang is a postdoctoral fellow of The Institute for Advanced Studies at Wuhan University, China. Gang Zhou is a postdoctoral fellow of The Institute for Advanced Studies at Wuhan University, China.

1. Introduction 2. Generation of a-siloxy radicals with a-silyl alcohols through radical Brook rearrangement2.1 Radical initiated reactions2.2 Metal-catalyzed reactions2.3 Photocatalyzed reactions2.4 Other reactions 3. Generation of a-siloxy radicals with acylsilanes through radical Brook rearrangement3.1 Radical initiated reactions3.2 Metal-catalyzed reactions3.3 Photocatalyzed reactions 4. Generation of a-siloxy silyl radicals with (TMS)3SiOH through radical Brook rearrangement4.1 Metallaphotoredox reactions4.2 Photoredox reactions4.3 Metallaphotoredox reactions with (TMS)3SiNHAd 5. Generation of siloxycarbenes for nucleophilic addition reaction5.1 Aldehydes or ketones as electrophiles5.2 Other electrophilic reagents 6. Generation of siloxycarbenes for insertion reactions6.1 Carbene insertion reactions into O?H bonds6.2 Carbene insertion reactions into N?H bonds6.3 Carbene insertion reactions into other X?H bonds6.4 Carbene insertion reactions into B?C bonds6.5 Carbene insertion reactions into C?H bonds 7. Generation of siloxycarbenes for cycloaddition reactions7.1 [2+1] cycloaddition with alkyne7.2 [2+1] cycloaddition with alkene7.3 [4+1] cycloaddition with diene7.4 Other cyclization reactions 8. Generation of siloxycarbenes for metal siloxycarbene reactions 9. Generation of silenes through radical Brook rearrangement9.1 Insertion reactions9.2 Cycloaddition reactions9.3 Other reactions