Del 139 - Cancer Treatment and Research
Radiation Oncology Advances
Häftad, Engelska, 2010
Av Søren M. Bentzen, Paul M. Harari, T. Rockwell Mackie, Minesh P. Mehta
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Fri frakt för medlemmar vid köp för minst 249 kr.from combining radiation with a molecular targeted agent – namely cetuximab, a recombinant mouse/human chimeric monoclonal antibody against the Epidermal Growth Factor (EGF) receptor [4] Astsaturov, Cohen and Harari present a more indepth review of the biology of the EGF Receptor and its signaling pathway in Chap. 7 as a potential target in combination with fractionated radiotherap y for head and neck squamous cell carcinoma (HNSCC). A flurry of agents are under de velopment for targeting EGFR and in March 2006, the US Food and Drugs Administration approved cetuximab combined with radiation as a primary treatment option for patients with loco-regionally advanced HNSCC in whom chemoradiation therapy is deemed not to be an option. While blocking the EGF pathway during fractionated radiotherapy may seem an obvious strategy [5], the rationale for combining antiangiogenic and antivascular targeting agents with radiation may be less intuitive. However, recent research shows that there are several reasons why this could result in a therapeutic gain in practice. Chapter 8 is a review of this rapidly expanding field by Citrin and Camphausen. Targeted agents combined with radiation may offer new opportunities in the treatment of central nervous system malignancies, a tumor type where the outlook remains poor despite some recent progress [6]. Current attempts to overcome rad- tion resistance in these tumors on the basis of an improved understanding of their molecular biology are the topic of Chap. 9 by Chakravarti and Palanichamy.
Produktinformation
- Utgivningsdatum2010-11-29
- Mått155 x 235 x undefined mm
- FormatHäftad
- SpråkEngelska
- SerieCancer Treatment and Research
- Antal sidor336
- FörlagSpringer-Verlag New York Inc.
- ISBN9781441942210