Quinone Methides

STEVEN E. ROKITA, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland. His research interests lie in sequence and conformation specific reactions of nucleic acids, enzyme-mediated activation of substrates and coenzymes, halogenation and dehalogenation reactions in biology, aromatic substitution and quinone methide generation in bioorganic chemistry, copper- and nickel-mediated reactions in bioinorganic chemistry, and electron transfer in biopolymers. Dr. Rokita has more than eighty publications and twelve patents on file to his credit.

• Chapter 1: Photochemical Generation and Characterization of Quinone-Methides (Matthew Lukeman). Chapter 2: Modeling Properties and Reactivity of Quinone Methides by DFT calculations (Mauro Freccero and Filippo Doria).Chapter 3: Quinone Methide Stabilization by Metal Complexation (David Milstein and Elena Poverenov).Chapter 4: Intermolecular Applications of o-Quinone Methides (o-QMs) Anionically Generated at Low Temperatures; Kinetic Conditions (Thomas Pettus and Liping Pettus).Chapter 5: Self-Immolative Dendrimers Based on Quinone Methides (Doron Shabat and Rotem Erez).Chapter 6: Ortho-Quinone Methides in Tocopherol Chemistry (Thomas Rosenau and Stefan Böhmdorfer).Chapter 7: Characterizing Quinone Methides by Spectral Global Fitting and 13C Labeling (Edward B. Skibo).Chapter 8: Natural Diterpene and Triterpene Quinone Methides: Structures, Synthesis and Biological Potentials (Qibing Zhou).Chapter 9: Reversible Alkylation of DNA by Quinone Methides (Steven E. Rokita).Chapter 10: Formation and Reactions of Xenobiotic Quinone Methides in Biology (Judy L. Bolton and John A. Thompson).Chapter 11: Quinone Methides and Aza-Quinone Methides as Latent Alkylating Species in the Design of Mechanism-Based Inhibitors of Serine Proteases and ß-Lactamases (Michèle Reboud-Ravaux and Michel Wakselman).Chapter 12: Quinone Methides in Lignification (John Ralph, Paul F. Schatz, Fachuang Lu,Hoon Kim, Takuya Akiyama, and Stephen F. Nelsen).

"Well produced, concise and well illustrated by structures, reactions and spectra." (Phytochemistry, January 2010) "I believe that many chemists, both in academia and in industry, will find this volume to be a useful addition to their libraries. I would also recommend this book for institutional library collections, where it will serve as a valuable reference source." (Journal of the American Chemical Society, October 2009)"This volume, part of a series structured to illustrate the widest range of literature on specific reactive intermediaries, illustrates the literature on quinone methides, quinone analogues in which carbonyl oxygens are replaced by methylene groups." (Book News, September 2009)