Quasispecies: From Theory to Experimental Systems

Esteban Domingo is a professor at the Spanish Research Council at Centro de Biología Molecular Severo Ochoa (Madrid) and President of the Spanish Society of Virology. He is a member of EMBO and Real Academía de Ciencias Exactas, Físicas y Naturales. Peter Schuster, em. professor of University of Vienna is a member of Leopoldina, Nationale Akademie der Wissenschaften, National Academy of Sciences USA, European Academy of Sciences and Arts and several other institutions. He worked together with Manfred Eigen and developed together with him the concepts of "quasispecies" and "hypercycles".

• What is a quasispecies?- Historical origins and current scope.- The nucleation of semantic information in prebiotic matter.- Evolution of RNA-based networks.- Quasispecies on fitness landscapes.- Mathematical models of quasispecies theory and exact results for the dynamics.- Theoretical Models of Generalized Quasispecies.- Theories of lethal mutagenesis: from error catastrophe to lethal defection.- Estimating fitness of viral quasispecies from next-generation sequencing data.- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models.- Cooperative Interaction within RNA Virus Mutant Spectra.- Arenavirus Quasispecies And Their Biological Implications.- Models of viral population dynamics.- Fidelity variants and RNA quasispecies.- Antiviral strategies based on lethal mutagenesis and error threshold.