This book constitutes the proceedings of the 19th International Conference on Quantitative Evaluation Systems, QEST 2022, held in Warsaw, Poland, in September 2022.The 19 full papers presented together with 1 keynote paper were carefully reviewed and selected from 44 submissions. The papers are organized in the following topics: program analysis; parameter synthesis; markovian agents and population models; dynamical systems; tools; applications and automata theory; and applications.