Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

• Part 1. Fundamentals of quadruplexes and their biology Fundamentals of G-quadruplex biologyF. Brad JohnsonQuadruplex structure and diversityFernaldo Richtia Winnerdy and Anh Tuân PhanPart 2. Quadruplex targets in human and other organismsTelomeric quadruplexes as therapeutic targetsSefan Asamitsu, Norifumi Shioda and Hiroshi SugiyamaViral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapyEmanuela Ruggiero and Sara N. RichterQuadruplex detection in human cellsDavid MonchaudPart 3. Discovery and design of quadruplex-binding compoundsAn overview of quadruplex ligands: Their common features and chemotype diversity Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo DoriaMolecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand bindingJiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb HaiderQuadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancersAnton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-FichouClick and combinatorial approaches to quadruplex ligand discoveryJyotirmayee Dash, Puja Saha and Khushnood FatmaQuadruplex nucleic acids in KRAS targeted-cancer therapyLuigi E. XodoTranscriptional regulation of MYC through G-quadruplex structuresSumirtha Balaratnam and John S. SchneeklothKIT promoter: Structure, function and targetingSilvia Ceschi and Claudia SissiQuadruplex targets in neurodegenerative diseasesJanez PlavecMetal complexes as G-quadruplex bindersTim Kench and Ramon VilarChallenges in developing small-molecule quadruplex therapeutics Stephen Neidle