Del i serien Methods in Molecular Biology

Protocols for Oligonucleotides and Analogs

Synthesis and Properties

Inbunden, Engelska, 1993

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Leading researchers summarize and describe their experience and techniques for synthesizing oligonucleotides and their analogs. The protocols presented cover all DNA analogs that have been studied to date and constitute the single most extensive source of knowledge about DNA chemistry available.

Produktinformation

Utgivningsdatum1993-08-31
Mått155 x 235 x 38 mm
Vikt896 g
FormatInbunden
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor502
Upplaga1993
FörlagHumana Press Inc.
ISBN9780896032811

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Biologi inom Naturvetenskap och teknik
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A Brief History of Oligonucleotide Synthesis.- Oligonucleotide Synthesis.- Oligodeoxyribonucleotides Synthesis.- Oligodeoxynucleotide Synthesis.- Oligoribonucleotide Synthesis.- Synthesis of 2?-O-Alkyloligoribonucleotides.- An Improved Method for the Synthesis and Deprotection of Methylphosphonate Oligonucleotides.- Oligonucleoside Phosphorothioates.- Synthesis and Purification of Phosphorodithioate DNA.- Oligodeoxyribonucleotide Phosphotriesters.- Oligonucleoside Boranophosphate (Borane Phosphonate).- Oligonucleotide Phosphorofluoridates and Fluoridites.- ?-Oligodeoxynucleotides.- Stereospecific Synthesis of P-Chiral Analogs of Oligonucleotides.- Oligonucleotide Analogs with Dimethylenesulfide, -sulfoxide, and -sulfone Groups Replacing Phosphodiester Linkages.- Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages.- Scale-Up of Oligonucleotide Synthesis.- Large-Scale Oligonucleotide Synthesis Using the Solid-Phase Approach.- Solid-Phase Supports for Oligonucleotide Synthesis.