Proteomics and Protein-Protein Interactions

• Introduction: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design.- Yeast Two-Hybrid Protein-Protein Interaction Networks.- The Use of Mass Spectrometry in Studying Protein-Protein Interaction.- Molecular Recognition in the Immune System.- Computational Methods for Predicting Protein-Protein Interactions.- Protein-Protein Docking Methods.- Thermochemistry of Binary and Ternary Protein Interactions Measured by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and Anti-gp120.- Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling.- Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other Functionally Related Protein Domains.- The Structure and Molecular Interactions of the Bromodomain.- SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60src (Src).- Disrupting Protein-Protein Interaction: Therapeutic Tools Against Brain Damage.- A Thermodynamic Guide to Affinity Optimization of Drug Candidates.

"While there are several books on Protemics on the market currently, Protemics and Protein-Protein Interactions is unique in that it focuses on technical issues and on the protein interactome itself. This very important and active research area is brought together by some of the leaders in the field to present a coherent entry point into a field that appeals to many. This will be a valuable and long-lived volume. It will certainly make a timely addition to any library or book collection." (Mark A. Lemmon, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania)